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Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching.
Hermle, Dominik; Schubert, Robin; Barallon, Pascal; Ilg, Winfried; Schüle, Rebecca; Reilmann, Ralf; Synofzik, Matthis; Traschütz, Andreas.
Afiliación
  • Hermle D; Division Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Schubert R; George-Huntington-Institute, Münster, Germany.
  • Barallon P; George-Huntington-Institute, Münster, Germany.
  • Ilg W; Section Computational Sensomotorics, Hertie Institute for Clinical Brain Research, Tübingen, Germany.
  • Schüle R; Centre for Integrative Neuroscience (CIN), Tübingen, Germany.
  • Reilmann R; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Synofzik M; Division of Neurodegenerative Disease, Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Traschütz A; Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Ann Clin Transl Neurol ; 11(5): 1097-1109, 2024 May.
Article en En | MEDLINE | ID: mdl-38590028
ABSTRACT

OBJECTIVE:

Voluntary upper limb movements are an ecologically important yet insufficiently explored digital-motor outcome domain for trials in degenerative ataxia. We extended and validated the trial-ready quantitative motor assessment battery "Q-Motor" for upper limb movements with clinician-reported, patient-focused, and performance outcomes of ataxia.

METHODS:

Exploratory single-center cross-sectional assessment in 94 subjects (46 cross-genotype ataxia patients; 48 matched controls), comprising five tasks measured by force transducer and/or position field Finger Tapping, diadochokinesia, grip-lift, and-as novel implementations-Spiral Drawing, and Target Reaching. Digital-motor measures were selected if they discriminated from controls (AUC >0.7) and correlated-with at least one strong correlation (rho ≥0.6)-to the Scale for the Assessment and Rating of Ataxia (SARA), activities of daily living (FARS-ADL), and the Nine-Hole Peg Test (9HPT).

RESULTS:

Six movement features with 69 measures met selection criteria, including speed and variability in all tasks, stability in grip-lift, and efficiency in Target Reaching. The novel drawing/reaching tasks best captured impairment in dexterity (|rho9HPT| ≤0.81) and FARS-ADL upper limb items (|rhoADLul| ≤0.64), particularly by kinematic analysis of smoothness (SPARC). Target hit rate, a composite of speed and endpoint precision, almost perfectly discriminated ataxia and controls (AUC 0.97). Selected measures in all tasks discriminated between mild, moderate, and severe impairment (SARA upper limb composite 0-2/>2-4/>4-6) and correlated with severity in the trial-relevant mild ataxia stage (SARA ≤10, n = 20).

INTERPRETATION:

Q-Motor assessment captures multiple features of impaired upper limb movements in degenerative ataxia. Validation with key clinical outcome domains provides the basis for evaluation in longitudinal studies and clinical trial settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia / Extremidad Superior Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Clin Transl Neurol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia / Extremidad Superior Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Clin Transl Neurol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos