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Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity.
Luck, Maria I; Subillaga, Erick J; Borenstein, Ronen; Sabo, Yosef.
Afiliación
  • Luck MI; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
  • Subillaga EJ; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
  • Borenstein R; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
  • Sabo Y; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Sci Rep ; 14(1): 8230, 2024 04 08.
Article en En | MEDLINE | ID: mdl-38589437
ABSTRACT
The human respiratory syncytial virus (hRSV) and the human metapneumovirus (hMPV) are important human respiratory pathogens from the Pneumoviridae family. Both are responsible for severe respiratory tract infections in infants, young children, elderly individuals, adults with chronic medical conditions, and immunocompromised patients. Despite their large impact on human health, vaccines for hRSV were only recently introduced, and only limited treatment options exist. Here we show that Ginkgolic acid (GA), a natural compound from the extract of Ginkgo biloba, with known antiviral properties for several viruses, efficiently inhibits these viruses' infectivity and spread in cultures in a dose-dependent manner. We demonstrate that the drug specifically affects the entry step during the early stages on the viruses' life cycle with no effect on post-entry and late stage events, including viral gene transcription, genome replication, assembly and particles release. We provide evidence that GA acts as an efficient antiviral for members of the Pneumoviridae family and has the potential to be used to treat acute infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Virosis / Salicilatos / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio / Infecciones por Paramyxoviridae / Metapneumovirus Límite: Adult / Aged / Child / Child, preschool / Humans / Infant Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Virosis / Salicilatos / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio / Infecciones por Paramyxoviridae / Metapneumovirus Límite: Adult / Aged / Child / Child, preschool / Humans / Infant Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido