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School performance and educational achievement in children exposed to maternal cancer in utero.
Greiber, Iben Katinka; Viuff, Jakob Hansen; Karlsen, Mona Aarenstrup; Lidegaard, Øjvind; Mikkelsen, Anders Preztmann; Hjortshøj, Cristel Sørensen; Storgaard, Lone; Mellemkjær, Lene.
Afiliación
  • Greiber IK; Department of Gynecology and Obstetrics, Rigshospitalet, Juliane Marie Centre, Kobenhavn, Denmark iben.katinka.greiber@regionh.dk.
  • Viuff JH; Danish Cancer Society Research Center, Kobenhavn, Denmark.
  • Karlsen MA; Danish Cancer Society Research Center, Kobenhavn, Denmark.
  • Lidegaard Ø; Department of Gynecology and Obstetrics, Rigshospitalet, Juliane Marie Centre, Kobenhavn, Denmark.
  • Mikkelsen AP; Department of Gynecology and Obstetrics, Rigshospitalet, Juliane Marie Centre, Kobenhavn, Denmark.
  • Hjortshøj CS; Department of Gynecology and Obstetrics, Rigshospitalet, Juliane Marie Centre, Kobenhavn, Denmark.
  • Storgaard L; Department of Pediatrics, Copenhagen University Hospital, Kobenhavn, Denmark.
  • Mellemkjær L; Department of Gynecology and Obstetrics, Rigshospitalet, Juliane Marie Centre, Kobenhavn, Denmark.
J Epidemiol Community Health ; 78(6): 395-401, 2024 May 09.
Article en En | MEDLINE | ID: mdl-38589221
ABSTRACT

BACKGROUND:

In utero exposure to maternal cancer and cancer treatment might influence the child's cognitive development. This study investigated if exposure to maternal cancer during fetal life impacted school performance and educational achievement as adults.

METHODS:

This nationwide retrospective cohort study identified all live-born children in Denmark between January 1978 and December 2013. Exposure was defined as maternal cancer diagnosis during pregnancy. Four partly overlapping birth cohorts were constructed depending on the outcome of interest (1) receiving special educational support for birth years 2001-2013; (2) grade point average (GPA) at the final exams after 10th grade for 1986-2003; (3) educational achievement at 20 years for 1978-1998; and (4) education at 30 years for 1978-1988. Logistic and linear models were adjusted for birth year, maternal age, maternal education and maternal death.

RESULTS:

The estimated probability of receiving special educational support was similar in the exposed group and the reference (adjusted OR 0.96; 95% CI 0.46 to 1.77, non-significant). The GPA did not statistically differ (0.13 grade points; 95% CI -0.18 to 0.45, non-significant). The achieved educational levels were similar for the exposed group and the reference at 20 years, with an adjusted OR of 1.07 (95% CI 0.82 to 1.40) for low versus medium educational level, and at 30 years with an adjusted OR of 0.73 (95% CI 0.35 to 1.50) for low versus high educational level and of 1.07 (95% CI 0.66 to 1.72) for medium versus high educational level.

CONCLUSION:

Our findings did not indicate poorer performance in compulsory school nor impairment of adult educational achievement after exposure to maternal cancer in utero.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Escolaridad / Éxito Académico / Neoplasias Límite: Adolescent / Adult / Child / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Epidemiol Community Health Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Escolaridad / Éxito Académico / Neoplasias Límite: Adolescent / Adult / Child / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Epidemiol Community Health Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido