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Probiotics induce intestinal IgA secretion in weanling mice potentially through promoting intestinal APRIL expression and modulating the gut microbiota composition.
Zhao, Maozhen; Liang, Xi; Meng, Yang; Lu, Haiyan; Lin, Kai; Gong, Pimin; Liu, Tongjie; Yi, Huaxi; Pan, Jiancun; Zhang, Yongjiu; Zhang, Zhe; Zhang, Lanwei.
Afiliación
  • Zhao M; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Liang X; College of Public Health, Qingdao University, Qingdao, 266000, China.
  • Meng Y; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Lu H; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Lin K; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Gong P; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Liu T; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Yi H; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Pan J; Heilongjiang Feihe Dairy Co., Ltd., Qiqihar, 161000, China.
  • Zhang Y; Heilongjiang Feihe Dairy Co., Ltd., Qiqihar, 161000, China.
  • Zhang Z; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
  • Zhang L; College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
Food Funct ; 15(9): 4862-4873, 2024 May 07.
Article en En | MEDLINE | ID: mdl-38587236
ABSTRACT
Intestinal infections are strongly associated with infant mortality, and intestinal immunoglobulin A (IgA) is important to protect infants from intestinal infections after weaning. This study aims to screen probiotics that can promote the production of intestinal IgA after weaning and further explore their potential mechanisms of action. In this study, probiotics promoting intestinal IgA production were screened in weanling mouse models. The results showed that oral administration of Bifidobacterium bifidum (B. bifidum) FL228.1 and Bifidobacterium bifidum (B. bifidum) FL276.1 significantly enhanced IgA levels in the small intestine and upregulated the expression of a proliferation-inducing ligand (APRIL) and its upstream regulatory factor toll-like receptor 4 (TLR4). Furthermore, B. bifidum FL228.1 upregulated the relative abundance of Lactobacillus, while B. bifidum FL276.1 increased the relative abundance of Marvinbryantia and decreased Mucispirillum, further elevating intestinal IgA levels. In summary, B. bifidum FL228.1 and B. bifidum FL276.1 can induce IgA production in the intestinal tract of weanling mice by promoting intestinal APRIL expression and mediating changes in the gut microbiota, thus playing a significant role in enhancing local intestinal immunity in infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Probióticos / Microbioma Gastrointestinal / Bifidobacterium bifidum Límite: Animals Idioma: En Revista: Food Funct Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Probióticos / Microbioma Gastrointestinal / Bifidobacterium bifidum Límite: Animals Idioma: En Revista: Food Funct Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido