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Azithromycin reduces bronchial wall thickening in infants with cystic fibrosis.
Chen, Yuxin; Charbonnier, Jean-Paul; Andrinopoulou, Eleni-Rosalina; Sly, Peter D; Stick, Stephen M; Tiddens, Harm A W M.
Afiliación
  • Chen Y; Department of Paediatrics, Division of Respiratory Medicine and Allergology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
  • Charbonnier JP; Thirona, Nijmegen, the Netherlands.
  • Andrinopoulou ER; Department of Biostatistics, Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Sly PD; Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
  • Stick SM; Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Health and Medical Sciences, University of Western Australia, Perth, WA, Australia; Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, WA, Australia.
  • Tiddens HAWM; Department of Paediatrics, Division of Respiratory Medicine and Allergology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands; Thirona, Nijmegen, the Netherlands. Electronic address: h.tiddens@era
J Cyst Fibros ; 23(5): 870-873, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38584038
ABSTRACT

BACKGROUND:

COMBAT-CF showed that children aged 0-3 years treated with azithromycin did clinically better than placebo but there was no effect on CT-scores. We reanalysed CTs using an automatic bronchus-artery (BA) analysis.

METHOD:

Inspiratory and expiratory CTs at 12 and 36 months were analysed. BA-analysis measures BA-diameters bronchial outer wall (Bout), bronchial inner wall (Bin), artery (A), and bronchial wall thickness (Bwt) and computes BA-ratios Bout/A and Bin/A for bronchial widening, Bwt/A and Bwa/Boa (bronchial wall area/bronchial outer area) for bronchial wall thickening. Low attenuation regions (LAR) were analysed using an automatic method. Mixed-effect model was used to compare BA-outcomes at 36 months between treatment groups.

RESULTS:

228 CTs (59 placebo; 66 azithromycin) were analysed. The azithromycin group had lower Bwa/Boa (p = 0.0034) and higher Bin/A (p = 0.001) relative to placebo. Bout/A (p = 0.0088) was higher because of a reduction in artery diameters which correlated to a reduction in LAR.

CONCLUSION:

Azithromycin-treated infants with CF show a reduction in bronchial wall thickness and possibly a positive effect on lung perfusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquios / Tomografía Computarizada por Rayos X / Azitromicina / Fibrosis Quística / Antibacterianos Límite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Cyst Fibros Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquios / Tomografía Computarizada por Rayos X / Azitromicina / Fibrosis Quística / Antibacterianos Límite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Cyst Fibros Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos