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Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens.
Tang, Lian-Yu; Zhang, Ya-Zhao; Gao, Yun; Tsering, Tashi; Jia, Jingming; Wang, Anhua.
Afiliación
  • Tang LY; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Zhang YZ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Gao Y; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Tsering T; Traditional Tibetan Medical Research & Study Institute of Regional Traditional Tibetan Medical Hospital, Lhasa, People's Republic of China. Electronic address: zhaxi75@126.com.
  • Jia J; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China. Electronic address: jiajingming@163.com.
  • Wang A; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China. Electronic address: sywanganhua@163.com.
Fitoterapia ; 175: 105954, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38583638
ABSTRACT
Six previously undescribed diterpenoid glucosides, along with four known compounds, were isolated from the aerial parts of Sigesbeckia glabrescens. The structures and absolute configurations of undescribed compounds were elucidated using extensive spectroscopic techniques, ECD calculations and chemical methods. Compounds 1 and 8 exhibited anti-inflammatory activity against LPS-induced NO production in RAW 264.7 macrophages, with compound 8 demonstrating significant inhibitory activity compared to positive control minocycline, boasting an IC50 value at 14.20 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Componentes Aéreos de las Plantas / Diterpenos / Fitoquímicos / Glucósidos / Antiinflamatorios / Óxido Nítrico Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Componentes Aéreos de las Plantas / Diterpenos / Fitoquímicos / Glucósidos / Antiinflamatorios / Óxido Nítrico Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos