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Decreased clinical performance in TGA-ASO patients after RVOT interventions; a multicenter European collaboration.
Engele, Leo J; González-Fernández, Víctor; Mulder, Barbara J M; Ruperti-Repilado, Francisco Javier; Abia, Raquel Ladrón; van der Vlist, Kim; Buendía, Francisco; Rueda, Joaquin; Gabriel, Harald; Schrutka, Lore; Bouchardy, Judith; Schwerzmann, Markus; Possner, Mathias; Greutmann, Matthias; Gallego, Pastora; Ladouceur, Magalie; Jongbloed, Monique R M; Tobler, Daniel; Dos, Laura; Bouma, Berto J.
Afiliación
  • Engele LJ; CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Amsterdam University Medical Center, Amsterdam, the Netherlands.
  • González-Fernández V; Hospital Universitari Vall d'Hebron, CIBERCV and European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD Heart), Barcelona, Spain.
  • Mulder BJM; CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Amsterdam University Medical Center, Amsterdam, the Netherlands.
  • Ruperti-Repilado FJ; University Hospital, University of Basel, Switzerland.
  • Abia RL; Hospital Universitario Virgen del Rocio and European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD Heart), Seville, Spain.
  • van der Vlist K; CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Amsterdam University Medical Center, Amsterdam, the Netherlands.
  • Buendía F; Hospital Universitari i Politècnic La Fe and CIBERCV, València, Spain.
  • Rueda J; Hospital Universitari i Politècnic La Fe and CIBERCV, València, Spain.
  • Gabriel H; Medical University of Vienna, Austria.
  • Schrutka L; Medical University of Vienna, Austria.
  • Bouchardy J; University Hospital Lausanne, Switzerland; University Hospital of Geneva, Switzerland.
  • Schwerzmann M; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Possner M; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Greutmann M; University Heart Center Zurich, Switzerland.
  • Gallego P; Hospital Universitario Virgen del Rocio and European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD Heart), Seville, Spain.
  • Ladouceur M; Hôpital Européen Georges Pompidou, AP-HP, Paris Cité University, Centre de Recherche Cardiovasculaire de Paris, INSERM U970, Paris, France.
  • Jongbloed MRM; CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Leiden University Medical Center, Department of Cardiology and Anatomy & Embryology, Leiden, the Netherlands.
  • Tobler D; University Hospital, University of Basel, Switzerland.
  • Dos L; Hospital Universitari Vall d'Hebron, CIBERCV and European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD Heart), Barcelona, Spain.
  • Bouma BJ; CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address: b.j.bouma@amsterdamumc.nl.
Int J Cardiol ; 407: 132027, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-38583591
ABSTRACT

BACKGROUND:

In patients with transposition of the great arteries and an arterial switch operation (TGA-ASO) right ventricular outflow tract (RVOT) obstruction is a common complication requiring one or more RVOT interventions.

OBJECTIVES:

We aimed to assess cardiopulmonary exercise capacity and right ventricular function in patients stratified for type of RVOT intervention.

METHODS:

TGA-ASO patients (≥16 years) were stratified by type of RVOT intervention. The following outcome parameters were included predicted (%) peak oxygen uptake (peak VO2), tricuspid annular plane systolic excursion (TAPSE), tricuspid Lateral Annular Systolic Velocity (TV S'), right ventricle (RV)-arterial coupling (defined as TAPSE/RV systolic pressure ratio), and N-terminal proBNP (NT-proBNP).

RESULTS:

447 TGA patients with a mean age of 25.0 (interquartile range (IQR) 21-29) years were included. Patients without previous RVOT intervention (n = 338, 76%) had a significantly higher predicted peak VO2 (78.0 ± 17.4%) compared to patients with single approach catheter-based RVOT intervention (73.7 ± 12.7%), single approach surgical RVOT intervention (73.8 ± 28.1%), and patients with multiple approach RVOT intervention (66.2 ± 14.0%, p = 0.021). RV-arterial coupling was found to be significantly lower in patients with prior catheter-based and/or surgical RVOT intervention compared to patients without any RVOT intervention (p = 0.029).

CONCLUSIONS:

TGA patients after a successful arterial switch repair have a decreased exercise capacity. A considerable amount of TGA patients with either catheter or surgical RVOT intervention perform significantly worse compared to patients without RVOT interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transposición de los Grandes Vasos Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transposición de los Grandes Vasos Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos