High-resolution magnetic resonance imaging can predict osteoarthritic progression after medial meniscus posterior root injury: randomized in vivo experimental study in a rabbit model.
J ISAKOS
; 9(4): 526-533, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38583525
ABSTRACT
IMPORTANCE The field of meniscal root preservation has undergone significant advancement over the past decades; however, the challenge remains to fully understand whether meniscal root repair can ultimately arrest or delay osteoarthritic changes. OBJECTIVE:
To assess longitudinal changes in articular cartilage, subchondral bone, and progression to meniscal extrusion (ME) using high-resolution magnetic resonance imaging (MRI).METHODS:
Medial meniscus posterior root tear was surgically induced in 39 New Zealand white rabbits. Animals were randomly assigned into three experimental groups partial meniscectomy after root tear (PM, n â= â13); root tear left in situ (CT, n â= â13); and transtibial root repair (RR, n â= â13). Contralateral limbs were used as healthy controls. High resolution 4.7 Tesla MRI of the knee joint was performed at baseline, after 2-, and 4-months of post-surgery. Cartilage thickness was calculated in medial and lateral compartments. In addition, the evaluation of ME, subchondral bone edema and healing potential after root repair were assessed too.RESULTS:
Progressive cartilage thinning, ME, and subchondral bone edema were evident in all 3 study groups after 4-months of follow-up. The mean cartilage thickness in the PM group was 0.53 âmm (±0.050), 0.57 âmm (±0.05) in the CT group, and 0.60 âmm (±0.08) in the RR group. The PM group exhibited significantly higher cartilage loss when compared to the CT and RR groups (p â< â0.001). Moreover, progressive ME and subchondral bone edema were associated with a more severe cartilage loss at the final follow-up.CONCLUSION:
Meniscal root repair did not halt but rather reduced the progression of osteoarthritis (OA). Degenerative changes worsened at a rapid rate in the PM group compared to the RR and CT groups. Early cartilage swelling, persistent subchondral edema, and progressive ME predicted a more severe progression to knee OA in the CT and RR groups. LEVEL OF EVIDENCE II.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Meniscos Tibiales
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Imagen por Resonancia Magnética
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Cartílago Articular
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Progresión de la Enfermedad
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Modelos Animales de Enfermedad
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Lesiones de Menisco Tibial
Límite:
Animals
Idioma:
En
Revista:
J ISAKOS
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido