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Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet.
Yuan, Qianhua; Luo, Mengliu; Xie, Yutong; Song, Wanhan; Wang, Ya; Deng, Dazhang; Chen, Shuyan; Guo, Honghui.
Afiliación
  • Yuan Q; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Luo M; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Xie Y; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Song W; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Wang Y; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Deng D; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Chen S; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
  • Guo H; Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. guohh1999@gdmu.edu.cn.
Biogerontology ; 2024 Apr 06.
Article en En | MEDLINE | ID: mdl-38582786
ABSTRACT
Aging entails the progressive decline in the body's self-regulation and functionality over time. Notably, obesity and aging exhibit parallel phenotypes, with obesity further accelerating the aging process across multiple dimensions and diminishing lifespan. In this study, we explored the impact of trans fatty acid (TFA) consumption on the overall health and lifespan of male Drosophila melanogaster under an isocaloric high-sugar and high-fat diet. Our results indicate that TFA intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in flies fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, TFA exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies. Collectively, chronic TFA consumption expedites the aging process and reduces the lifespan of male Drosophila melanogaster. These results contribute supplementary evidence regarding the adverse health effects associated with TFAs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biogerontology Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biogerontology Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos