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Two-center analysis of cannabis on venous thromboembolism risk after traumatic injury: A matched analysis.
Erwin, Casey R; Costantini, Todd W; Krzyzaniak, Andrea; Martin, Matthew J; Badiee, Jayraan; Rooney, Alexandra S; Haines, Laura N; Berndtson, Allison E; Bansal, Vishal; Sise, C Beth; Calvo, Richard Y; Sise, Michael J.
Afiliación
  • Erwin CR; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: erwin.casey@scrippshealth.org.
  • Costantini TW; Divison of Trauma and Acute Care Surgery, Department of Surgery, UCSD Medical Center, San Diego, CA, USA. Electronic address: tcostantini@health.ucsd.edu.
  • Krzyzaniak A; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: Krzyzaniak.Andrea@scrippshealth.org.
  • Martin MJ; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: matthew.martin@med.usc.edu.
  • Badiee J; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: jayraan@gmail.com.
  • Rooney AS; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: rooney.alexandra@scrippshealth.org.
  • Haines LN; Divison of Trauma and Acute Care Surgery, Department of Surgery, UCSD Medical Center, San Diego, CA, USA. Electronic address: lhaines@health.ucsd.edu.
  • Berndtson AE; Divison of Trauma and Acute Care Surgery, Department of Surgery, UCSD Medical Center, San Diego, CA, USA. Electronic address: aberndtson@health.ucsd.edu.
  • Bansal V; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: bansal.vishal@scrippshealth.org.
  • Sise CB; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: cbsise@gmail.com.
  • Calvo RY; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: calvo.richard@scrippshealth.org.
  • Sise MJ; Division of Trauma and Acute Care Surgery, Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA. Electronic address: sise.mike@scrippshealth.org.
Am J Surg ; 235: 115727, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38582739
ABSTRACT

BACKGROUND:

Conflicting evidence exists evaluating associations between cannabis (THC) and post-traumatic DVT.

METHODS:

Retrospective analysis (2014-2023) of patients ≥15yrs from two Level I trauma centers with robust VTE surveillance and prophylaxis protocols. Multivariable hierarchical regression assessed the association between THC and DVT risk. THC â€‹+ â€‹patients were direct matched to other drug use categories on VTE risk markers and hospital length of stay.

RESULTS:

Of 7365 patients, 3719 were drug-, 575 were THC â€‹+ â€‹only, 2583 were other drug+, and 488 were TCH+/other drug+. DVT rates by exposure group did not differ. TCH â€‹+ â€‹only patients had higher GCS scores, shorter hospital length of stay, and the lowest pelvic fracture and mortality rates. A total of 458 drug-, 453 other drug+, and 232 THC+/other drug â€‹+ â€‹patients were matched to 458, 453, and 232 THC â€‹+ â€‹only patients. There were no differences in DVT event rates in any paired sub-cohort set. Additionally, iteratively adjusted paired models did not show an association between THC and DVT.

CONCLUSIONS:

THC does not appear to be associated with increased DVT risk in patients with strict trauma chemoprophylaxis. Toxicology testing is useful for identifying substance abuse intervention opportunities, but not for DVT risk stratification in THC â€‹+ â€‹patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heridas y Lesiones / Tromboembolia Venosa Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Surg Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heridas y Lesiones / Tromboembolia Venosa Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Surg Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos