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High Efficacy of Ivermectin for Strongyloidiasis Treatment.
Sengthong, Chatchawan; Pinlaor, Somchai; Yingklang, Manachai; Haonon, Ornuma; Jantawong, Chanakan; Pinlaor, Porntip; Sithithaworn, Paiboon; Hongsrichan, Nuttanan.
Afiliación
  • Sengthong C; The Office of Disease Prevention and Control 7, Khon Kaen, Thailand.
  • Pinlaor S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  • Yingklang M; Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  • Haonon O; Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand.
  • Jantawong C; Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
  • Pinlaor P; Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand.
  • Sithithaworn P; Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  • Hongsrichan N; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Am J Trop Med Hyg ; 110(5): 951-952, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38579698
ABSTRACT
Infection with Strongyloides stercoralis is often asymptomatic but can be life-threatening in immunocompromised patients, which can be prevented by ivermectin (IVM) treatment. The efficacy of IVM has been reported to have lessened over time in some regions as a consequence of prolonged use and mass treatment campaigns. Ivermectin has been used in Thailand for more than a decade; therefore, we investigated the efficacy of a single dose (200 µg/kg) of IVM against in asymptomatic strongyloidiasis in northeastern Thailand. Fecal samples were collected before and 2 weeks after treatment and were analyzed for the presence of Strongyloides using a modified agar plate culture and the formalin-ethyl acetate concentration technique. Our results showed that single-dose IVM treatment successfully eliminated S. stercoralis infection in asymptomatic individuals in the endemic area with a 100% cure rate, indicating the high efficacy of IVM treatment in strongyloidiasis in northeast Thailand.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrongiloidiasis / Ivermectina / Strongyloides stercoralis / Heces Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrongiloidiasis / Ivermectina / Strongyloides stercoralis / Heces Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos