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Strategies to Improve Drug Delivery Across the Blood-Brain Barrier for Glioblastoma.
Narsinh, Kazim H; Perez, Edgar; Haddad, Alexander F; Young, Jacob S; Savastano, Luis; Villanueva-Meyer, Javier E; Winkler, Ethan; de Groot, John.
Afiliación
  • Narsinh KH; Department of Neurologic Surgery, University of California, San Francisco, CA, USA. kazim.narsinh@ucsf.edu.
  • Perez E; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA. kazim.narsinh@ucsf.edu.
  • Haddad AF; Department of Neurologic Surgery, University of California, San Francisco, CA, USA.
  • Young JS; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA.
  • Savastano L; Department of Neurologic Surgery, University of California, San Francisco, CA, USA.
  • Villanueva-Meyer JE; Department of Neurologic Surgery, University of California, San Francisco, CA, USA.
  • Winkler E; Department of Neurologic Surgery, University of California, San Francisco, CA, USA.
  • de Groot J; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA.
Curr Neurol Neurosci Rep ; 24(5): 123-139, 2024 05.
Article en En | MEDLINE | ID: mdl-38578405
ABSTRACT
PURPOSE OF REVIEW Glioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has been a dearth of effective new treatments. New approaches to drug delivery and clinical trial design are needed. RECENT

FINDINGS:

We discuss how the blood-brain barrier and tumor microenvironment pose challenges for development of effective therapies for glioblastoma. Next, we discuss treatments in development that aim to overcome these barriers, including novel drug designs such as nanoparticles and antibody-drug conjugates, novel methods of drug delivery, including convection-enhanced and intra-arterial delivery, and novel methods to enhance drug penetration, such as blood-brain barrier disruption by focused ultrasound and laser interstitial thermal therapy. Lastly, we address future opportunities, positing combination therapy as the best strategy for effective treatment, neoadjuvant and window-of-opportunity approaches to simultaneously enhance therapeutic effectiveness with interrogation of on-treatment biologic endpoints, and adaptive platform and basket trials as imperative for future trial design. New approaches to GBM treatment should account for the blood-brain barrier and immunosuppression by improving drug delivery, combining treatments, and integrating novel clinical trial designs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Límite: Humans Idioma: En Revista: Curr Neurol Neurosci Rep Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Límite: Humans Idioma: En Revista: Curr Neurol Neurosci Rep Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos