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Predictive value of free triiodothyronine to free thyroxine ratio on contrast-associated acute kidney injury and poor prognosis in euthyroid patients after percutaneous coronary intervention.
Zeng, Ji-Lang; Zhang, Li-Wei; Liang, Wen-Jia; You, Zhebin; Chen, Jun-Han; Chen, Li-Chuan; Lin, Kai-Yang; Guo, Yansong.
Afiliación
  • Zeng JL; Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Dongjie Street 134, Fuzhou, 350001, Fujian, China.
  • Zhang LW; Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, China.
  • Liang WJ; Fujian Heart Failure Center Alliance, Fuzhou, China.
  • You Z; Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Dongjie Street 134, Fuzhou, 350001, Fujian, China.
  • Chen JH; Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, China.
  • Chen LC; Fujian Heart Failure Center Alliance, Fuzhou, China.
  • Lin KY; Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Dongjie Street 134, Fuzhou, 350001, Fujian, China.
  • Guo Y; Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, China.
Int Urol Nephrol ; 56(9): 3023-3030, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38578391
ABSTRACT

PURPOSE:

The purpose of the study was to explore the predictive value of free triiodothyronine to free thyroxine ratio (FT3/FT4) on contrast-associated acute kidney injury (CA-AKI) and poor prognosis in euthyroid patients after percutaneous coronary intervention (PCI).

METHODS:

The present study included 3,116 euthyroid patients who underwent elective PCI. The main outcome was CA-AKI, and the secondary outcome was long-term mortality. All patients were divided into three groups according to the tertiles of FT3/FT4 levels.

RESULTS:

During hospitalization, a total of 160 cases (5.1%) of CA-AKI occurred. Restricted cubic spline (RCS) analysis indicated a linear and negative relationship between FT3/FT4 and CA-AKI risk (P for nonlinearity = 0.2621). Besides, the fully-adjusted logistic regression model revealed that patients in tertile 3 (low FT3/FT4 group) had 1.82 times [odds ratio (OR) 1.82, 95% confidence interval (CI) 1.13-3.02, P = 0.016] as high as the risk of CA-AKI than those in tertile 1 (high FT3/FT4 group). Similarly, patients in tertile 3 were observed to have a higher incidence of long-term mortality [fully-adjusted hazard ratio (HR) 1.58, 95% CI 1.07-2.32, P = 0.021]. Similarly, the Kaplan-Meier curves displayed significant differences in long-term mortality among the three groups (log-rank test, P < 0.001).

CONCLUSION:

In euthyroid patients undergoing elective PCI, low levels of FT3/FT4 were independently associated with an increased risk of CA-AKI and long-term mortality. Routine evaluation of FT3/FT4 may aid in risk stratification and guide treatment decisions within this particular patient group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroxina / Triyodotironina / Valor Predictivo de las Pruebas / Medios de Contraste / Lesión Renal Aguda / Intervención Coronaria Percutánea Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroxina / Triyodotironina / Valor Predictivo de las Pruebas / Medios de Contraste / Lesión Renal Aguda / Intervención Coronaria Percutánea Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos