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Functional analysis of airway remodeling is related with fibrotic mediators in asthmatic children.
Salles-Dias, Lucas P; Brandao-Rangel, Maysa A R; Cristina-Rosa, Amanda; Morais-Felix, Rayssa T; Oliveira-Freitas, Simone; Oliveira, Luis V F; Moraes-Ferreira, Renilson; Bachi, Andre L L; Coutinho, Elisa T; Frison, Claudio R; Abbasi, Asghar; Melamed, Dobroslav; Vieira, Rodolfo P.
Afiliación
  • Salles-Dias LP; Post-graduate Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil.
  • Brandao-Rangel MAR; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Cristina-Rosa A; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Morais-Felix RT; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Oliveira-Freitas S; Post-graduate Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil.
  • Oliveira LVF; Post-graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Evangelical University of Goias (UniEvangélica), Anápolis, GO, Brazil.
  • Moraes-Ferreira R; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Bachi ALL; Post-graduation Program in Health Science, University of Santo Amaro, Rua Isabel Schmidt, São Paulo, SP, Brazil.
  • Coutinho ET; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Frison CR; Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
  • Abbasi A; Division of Respiratory & Critical Care Physiology & Medicine, Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center, Torrance, CA, USA.
  • Melamed D; Division of Research and Development, Libipharm, Rehovot, Israel.
  • Vieira RP; Post-graduate Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil.
J Asthma ; 61(10): 1284-1293, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38577973
ABSTRACT

BACKGROUND:

Asthmatic children present variable degrees of airway inflammation, remodeling, and resistance, which correlate with disease control and severity. The chronic inflammatory process of the airway triggers airway remodeling, which reflects the degree of airway resistance. Pro-inflammatory and pro-fibrotic mediators are centrally involved in this process.

OBJECTIVE:

To investigate whether the levels of pulmonary and systemic pro-inflammatory and pro-fibrotic mediators present a correlation with the resistance of the respiratory system and of the proximal and distal airways.

METHODS:

39 Asthmatic children (persistent mild and moderate) and 39 non-asthmatic children (both between 6 and 13 years old) were evaluated for anthropometric characteristics, lung function and mechanics, and pulmonary and systemic immune responses.

RESULTS:

Asthmatic children showed an increased number of blood eosinophils (p < 0.04), basophils (p < 0.04), monocytes (p < 0.002) and lymphocytes (p < 0.03). In addition, asthmatic children showed impaired lung function, as demonstrated by FEV1 (p < 0.0005) and FEV1/FVC (p < 0.004), decreased total resistance of the respiratory system (R5Hz; p < 0.009), increased resistance of the proximal airways (R20Hz; p < 0.02), increased elastance (Z5Hz; p < 0.02) and increased reactance (X5Hz; p < 0.002) compared to non-asthmatic children. Moreover, the following inflammatory factors were significantly higher in asthmatic than non-asthmatic children GM-CSF in the breath condensate (BC) (p < 0.0001) and in the serum (p < 0.0001); TGF-beta in the BC (p < 0.0001) and in the serum (p < 0.004); IL-5 in the BC (p < 0.02) and in the serum (p < 0.01); IL-4 in the serum (p < 0.0002).

CONCLUSIONS:

Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Resistencia de las Vías Respiratorias / Remodelación de las Vías Aéreas (Respiratorias) Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Asthma Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Resistencia de las Vías Respiratorias / Remodelación de las Vías Aéreas (Respiratorias) Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Asthma Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido