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The diagnostic role of resting myocardial blood flow in STEMI patients after revascularization.
Yan, Ming; Shang, Hua; Guo, Xiaorui; Hao, Luping; Hou, Shuang; Zheng, Hongming.
Afiliación
  • Yan M; Department of Nuclear Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Shang H; Department of Nuclear Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Guo X; Department of Nuclear Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Hao L; Department of Nuclear Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Hou S; Department of Electronic Science and Technology, School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China.
  • Zheng H; Department of Nuclear Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Front Cardiovasc Med ; 11: 1364772, 2024.
Article en En | MEDLINE | ID: mdl-38576422
ABSTRACT

Background:

The value of semiquantitative resting myocardial perfusion imaging (MPI) in coronary artery disease (CAD) is limited. At present, quantitative MPI can be performed by a new cadmium zinc tellurium single-photon emission computed tomography (CZT-SPECT) scan. The quantitative index of resting myocardial blood flow (MBF) has received little attention, and its manifestations and clinical value in the presence of unstable coronary blood flow have not been clarified.

Purpose:

In patients with ST-segment elevation myocardial infarction (STEMI), whether resting MBF can provide additional value of blood flow than semi-quantitative resting MPI is not sure. We also explored the influencing factors of resting MBF.

Methods:

This was a retrospective clinical study. We included 75 patients with STEMI in the subacute phase who underwent resting MPI and dynamic scans after reperfusion therapy. General patient information, STEMI-related data, MPI, gated MPI (G-MPI), and resting MBF data were collected and recorded. According to the clinically provided culprit vessels, the resting MBF was divided into ischemic MBF and non-ischemic MBF. The paired Wilcoxon signed-rank test was used for resting MBF. The receiver operating characteristic (ROC) curves were used to determine the optimal threshold for ischemia, and multiple linear regression analysis was used to analyze the influencing factors of resting MBF.

Results:

There was a statistically significant difference between the ischemic MBF and non-ischemic MBF [0.59 (0.47-0.72) vs. 0.76 (0.64-0.93), p < 0.0001]. The ROC curve analysis revealed that resting MBF could identify ischemia to a certain extent, with a cutoff value of 0.5975, area under the curve (AUC) = 0.666, sensitivity = 55.8%, and specificity = 68.7%. Male sex and summed rest score (SRS) were influencing factors for resting MBF.

Conclusion:

To a certain extent, resting MBF can suggest residual ischemia after reperfusion therapy in patients with STEMI. There was a negative correlation between male sex, SRS, and ischemic MBF. A lower resting MBF may be associated with more severe myocardial ischemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza