Your browser doesn't support javascript.
loading
Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders.
Varden Gjerde, Kristian; Bartz-Johannessen, Christoffer; Steen, Vidar Martin; Andreassen, Ole A; Steen, Nils Eiel; Ueland, Thor; Lekva, Tove; Rettenbacher, Maria; Joa, Inge; Reitan, Solveig Klæbo; Johnsen, Erik; Kroken, Rune Andreas.
Afiliación
  • Varden Gjerde K; NKS Olaviken Gerontopsychiatric Hospital, Erdal, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway; NORMENT Centre of Excellence, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. Electronic address: kristian.varden.gjerde@olaviken.no.
  • Bartz-Johannessen C; NORMENT Centre of Excellence, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
  • Steen VM; NORMENT Centre of Excellence, Department of Clinical Science (K2), University of Bergen, Bergen, Norway; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
  • Andreassen OA; NORMENT Centre of Excellence, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Steen NE; NORMENT Centre of Excellence, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Ueland T; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Clinical Medicine, Thrombosis Research Center, UiT - The Arctic University of Norway, Tromsø, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Lekva T; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Rettenbacher M; Medical University of Innsbruck; Department of Psychiatry, Psychotherapy and Psychosomatics, Innsbruck, Austria.
  • Joa I; TIPS Center for Clinical Research in Psychosis, Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway; Department of Public Health, Faculty of Health Science, University of Stavanger, Stavanger, Norway.
  • Reitan SK; St. Olav University Hospital, Nidelv community mental health centre, Trondheim, Norway; Norwegian University of Science and Technology, Department of Mental Health, Trondheim, Norway.
  • Johnsen E; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway; NORMENT Centre of Excellence, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
  • Kroken RA; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway; NORMENT Centre of Excellence, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Schizophr Res ; 267: 223-229, 2024 May.
Article en En | MEDLINE | ID: mdl-38574562
ABSTRACT

BACKGROUND:

Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.

METHODS:

The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.

RESULTS:

The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.

CONCLUSIONS:

In our study, patients with schizophrenia - including the drug-naïve - have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Moléculas de Adhesión Celular / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Moléculas de Adhesión Celular / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos