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Whey protein supplementation reduced the liver damage scores of rats fed with a high fat-high fructose diet.
Yigit Ziolkowski, Asli; Senol, Nurgül; Aslankoç, Rahime; Samur, Gülhan.
Afiliación
  • Yigit Ziolkowski A; Faculty of Health Sciences, Nutrition and Dietetics Department, Süleyman Demirel University, Isparta, Turkey.
  • Senol N; Faculty of Health Sciences, Nutrition and Dietetics Department, Süleyman Demirel University, Isparta, Turkey.
  • Aslankoç R; Faculty of Medicine, Department of Physiology, Süleyman Demirel University, Isparta, Turkey.
  • Samur G; Faculty of Health Sciences, Nutrition and Dietetics Department, Hacettepe University, Ankara, Turkey.
PLoS One ; 19(4): e0301012, 2024.
Article en En | MEDLINE | ID: mdl-38573884
ABSTRACT
Different functional foods with bioactive nutrients are being explored for the management of NAFLD. Whey proteins are rich in bioactive peptides and are suggested to show antioxidant and anti-inflammatory effects. We aim to test the hypothesis that the whey protein supplementation following a high fat-high fructose (HFHF) diet would protect against liver damage, inflammation, endotoxemia and steatosis in male Wistar rats. 36 rats were randomized into four groups for 8 weeks as the HFHF diet group, HFHF diet and whey protein isolate (WPI-200mg/kg/day) group (HFHF+WPI), control (C) group, and C+WPI (200mg/kg/day) group. Rats fed with a HFHF diet had higher final body weight compared to C and C+WPI groups (p = 0.002). Thus, WPI showed no significant effects for the body weight of rats with a HFHF diet. On the other hand, the HFHF+WPI group had significantly lower abdominal circumference when compared with the HFHF group (p<0,001). Higher serum CRP levels were observed in the groups with a HFHF diet (p<0,001) and WPI supplementation showed no effects on CRP levels. Whey protein supplementation resulted with lower total liver damage score in HFHF+WPI group compared with the HFHF diet group (p<0,001). Conversely, higher liver damage scores were observed with the C+WPI group compared to C group (p<0,001). HFHF diet resulted with higher expression of TLR-4 in the liver meanwhile WPI supplementation showed no effects on liver TLR-4 expression. We observed higher colon Occludin expression in HFHF+WPI and C+WPI groups compared with HFHF and C groups (p<0,001). Our results showed that, whey protein supplementation might help improve liver damage associated with a high fat-high fructose diet and increase the expression of Occludin in the small intestine and colon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor Toll-Like 4 / Fructosa Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor Toll-Like 4 / Fructosa Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos