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Hericium VN, an undescribed compound isolated from Hericium erinaceus and its cytotoxic activity on human brain astrocytoma.
Mai Huong, Le; Huu Nghi, Do; Dinh Luyen, Nguyen; Thu Quynh, Dang; Huong, Phan Thi Thanh; Tai, Bui Huu; Kiem, Phan Van.
Afiliación
  • Mai Huong L; Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam.
  • Huu Nghi D; Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam.
  • Dinh Luyen N; Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam.
  • Thu Quynh D; Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam.
  • Huong PTT; Graduate University of Science and Technology, VAST, Cau Giay, Hanoi, Vietnam.
  • Tai BH; Institute of Marine Biochemistry, VAST, Cau Giay, Hanoi, Vietnam.
  • Kiem PV; Institute of Marine Biochemistry, VAST, Cau Giay, Hanoi, Vietnam.
J Asian Nat Prod Res ; 26(7): 850-857, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38572975
ABSTRACT
Hericium erinaceus is a species of mushroom with high nutritional value that is used mainly as food in tropical countries. Phytochemical study of H. erinaceus led to the isolation of an undescribed compound, named as hericium VN (1), together with nine known compounds, 1-(2-formyl-1-pyrrolyl)butanoic acid (2), herierin III (3), 5'-(methylthio)adenosine (4), adenosine (5), nicotinic acid (6), (22E,24R)-5α,8α-epidioxyergosta-6,9(11),22-trien-3ß-ol (7), 5α,8α-peroxycerevisterol (8), (22E,24R)-5α,8α-epidioxy-egosta-6,22-diene 3-O-ß-D-glucopyranoside (9), and cerevisterol (10) based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. The absolute configuration of compound 1 was determined by experimental combined with calculated electronic circular dichroism spectra. Compound 7 exhibited cytotoxic effects against brain tumor cell line CCF-STTG1 with the IC50 value of 15.50 µM, compared to that of the positive control compound, doxorubicin, which showed IC50 value of 15.84 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Ensayos de Selección de Medicamentos Antitumorales / Hericium Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Ensayos de Selección de Medicamentos Antitumorales / Hericium Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido