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Social relationships, amyloid burden, and dementia: The ARIC-PET study.
Groechel, Renée C; Liu, Albert C; Liu, Chelsea; Knopman, David S; Koton, Silvia; Kucharska-Newton, Anna M; Lutsey, Pamela L; Mosley, Thomas H; Palta, Priya; Sharrett, A Richey; Walker, Keenan A; Wong, Dean F; Gottesman, Rebecca F.
Afiliación
  • Groechel RC; National Institute of Neurological Disorders & Stroke Intramural Research Program National Institutes of Health Bethesda Maryland USA.
  • Liu AC; Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA.
  • Liu C; Department of Epidemiology George Washington University-Milken Institute School of Public Health Washington District of Columbia USA.
  • Knopman DS; Department of Neurology Mayo Clinic Rochester Minnesota USA.
  • Koton S; Department of Nursing The Stanley Steyer School of Health Professions Tel Aviv University Tel Aviv Israel.
  • Kucharska-Newton AM; Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA.
  • Lutsey PL; Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA.
  • Mosley TH; Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA.
  • Palta P; Department of Medicine University of Mississippi Medical Center Jackson Mississippi USA.
  • Sharrett AR; Department of Neurology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
  • Walker KA; Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA.
  • Wong DF; National Institute on Aging Intramural Research Program National Institutes of Health Bethesda Maryland USA.
  • Gottesman RF; Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA.
Alzheimers Dement (Amst) ; 16(2): e12560, 2024.
Article en En | MEDLINE | ID: mdl-38571965
ABSTRACT

INTRODUCTION:

This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.

METHODS:

Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.

RESULTS:

Among 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk.

DISCUSSION:

Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos