Progress in Targeting KRAS Directly.

Nissley, Dwight V; Stephen, Andrew G; Yi, Ming; McCormick, Frank

Nissley, Dwight V; Stephen, Andrew G; Yi, Ming; McCormick, Frank.

Afiliación

Nissley DV; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. dwight.nissley@nih.gov.
Stephen AG; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Yi M; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
McCormick F; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Methods Mol Biol ; 2797: 1-12, 2024.

Article en En | MEDLINE | ID: mdl-38570448

ABSTRACT

ABSTRACT

RAS research has entered the world of translational and clinical science. Progress has been based on our appreciation of the role of RAS mutations in different types of cancer and the effects of these mutations on the biochemical, structural, and biophysical properties of the RAS proteins themselves, particularly KRAS, on which most attention has been focused. This knowledge base, while still growing, has enabled creative chemical approaches to targeting KRAS directly. Our understanding of RAS signaling pathways in normal and cancer cells plays an important role for developing RAS inhibitors but also continues to reveal new approaches to targeting RAS through disruption of signaling complexes and downstream pathways.

Asunto(s)

Antineoplásicos; Neoplasias; Humanos; Proteínas Proto-Oncogénicas p21(ras)/genética; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Mutación; Neoplasias/metabolismo; Transducción de Señal; Antineoplásicos/farmacología

Palabras clave

GTP hydrolysis; Mutation frequency in cancer; Oncogenic alleles; RAS; Targeting RAS

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google