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Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report.
Tsuyuki, Tomohisa; Torigoe, Kenta; Shimizu, Masatoshi; Taira, Hiroshi; Sakamoto, Ryosuke; Abe, Shinichi; Kuwatsuka, Sayaka; Muta, Kumiko; Mukae, Hiroshi; Nishino, Tomoya.
Afiliación
  • Tsuyuki T; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Torigoe K; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Shimizu M; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Taira H; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Sakamoto R; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Abe S; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Kuwatsuka S; Department of Dermatology, Nagasaki University Hospital, Japan.
  • Muta K; Department of Nephrology, Nagasaki University Hospital, Japan.
  • Mukae H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
  • Nishino T; Department of Nephrology, Nagasaki University Hospital, Japan.
Intern Med ; 2024 Apr 02.
Article en En | MEDLINE | ID: mdl-38569906
ABSTRACT
A 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolone therapy was therefore initiated. The patient's renal function improved, and erythema disappeared. To our knowledge, this is the first report of DRESS caused by dapagliflozin, and the patient was successfully treated with prednisolone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón