Your browser doesn't support javascript.
loading
Toxicity of REEs, Th, and U: A Biodisponibility, Cytotoxicity, and Bioaccumulation Assessment in Marine Sediment.
Cordeiro, Suellen Gerônimo; Pereira, Ana Cláudia H; Endringer, Denise Coutinho; Moreira, Luana Santos; Carneiro, Maria Tereza W D; de Souza, Jefferson Rodrigues; Brandão, Geisamanda Pedrini.
Afiliación
  • Cordeiro SG; Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, 29075-910, Brazil.
  • Pereira ACH; Department of Pharmaceutical Sciences, University of Vila Velha, Vila Velha, ES, 29102-920, Brazil.
  • Endringer DC; Department of Pharmaceutical Sciences, University of Vila Velha, Vila Velha, ES, 29102-920, Brazil.
  • Moreira LS; Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, 29075-910, Brazil.
  • Carneiro MTWD; Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, 29075-910, Brazil.
  • de Souza JR; Laboratory of Chemical Sciences, State University of the Northern Rio de Janeiro, Campos Dos Goytacazes, RJ, 28013-602, Brazil.
  • Brandão GP; Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, 29075-910, Brazil. geisamanda@gmail.com.
Biol Trace Elem Res ; 2024 Apr 03.
Article en En | MEDLINE | ID: mdl-38568335
ABSTRACT
In this work, bioaccessibility tests for rare earth elements (REEs), Th, and U in marine sediment were carried out, in addition to complementary tests for cytotoxicity and bioaccumulation for the elements La, Ce, Eu, and Gd. The evaluation of human health risk through dermal absorption and oral ingestion was performed using the hazard quotient (HQ). According to the gastric digestion simulation (SBET), it was observed that the elements Ce and Nd exhibited higher absorption capacities in the human body (> 2 µg g-1). La and Sc presented intermediate concentrations (close to 1 µg g-1), while the remaining elements displayed concentrations below 0.5 µg g-1. In the gastrointestinal digestion extraction stage (PBET), all the elements maintained a similar absorption capacity to that observed in SBET, except for the absorption of Y which increased. The results of the bioaccumulation test conducted with fibroblast cells (L929) indicated that La and Eu had a 25% probability of intracellular accumulation. The cell viability test, with exposure to a standard REEs, Th, and U solution in 2% v v-1 HNO3 medium (until 100 µg mL-1) and an aqueous solution of La2O3, Gd(NO3)3, Ce(NO3)3, and Eu2O3 (until 1000 µg mL-1), did not demonstrate cytotoxic effects on fibroblast cells. Considering the ingestion hazard quotient (HQing) and dermal hazard quotient (HQderm) obtained, it was suggested that there is no significant risk of non-carcinogenic effects (< 1). However, they had higher HQing values compared to HQderm, indicating that REEs pose more significant risk to human health through oral ingestion absorption than dermal absorption.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos