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Exploring the bidirectional relationship between metabolic syndrome and thyroid autoimmunity: a Mendelian randomization study.
Chen, Kefan; Sun, Wei; He, Liang; Dong, Wenwu; Zhang, Dalin; Zhang, Ting; Zhang, Hao.
Afiliación
  • Chen K; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • Sun W; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • He L; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • Dong W; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • Zhang D; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • Zhang T; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • Zhang H; Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Front Endocrinol (Lausanne) ; 15: 1325417, 2024.
Article en En | MEDLINE | ID: mdl-38567309
ABSTRACT

Background:

Observational studies have reported a possible association between metabolic syndrome (MetS) and thyroid autoimmunity. Nevertheless, the relationship between thyroid autoimmunity and MetS remains unclear. The objective of this research was to assess the causal impact of MetS on thyroid autoimmunity through the utilization of Mendelian randomization (MR) methodology.

Methods:

We performed bidirectional MR to elucidate the causal relationship between MetS and their components and thyroid autoimmunity (positivity of TPOAb). Single nucleotide polymorphisms (SNPs) of MetS and its components were obtained from the publicly available genetic variation summary database. The Thyroidomics Consortium conducted a genome-wide association analysis, which provided summary-level data pertaining to thyroid autoimmunity. The study included several statistical methods, including the inverse variance weighting method (IVW), weighted median, simple mode, weight mode, and MR-Egger methods, to assess the causal link. In addition, to ensure the stability of the results, a sensitivity analysis was conducted.

Results:

IVW showed that MetS reduced the risk of developing thyroid autoimmunity (OR = 0.717, 95% CI = 0.584 - 0.88, P = 1.48E-03). The investigation into the causative association between components of MetS and thyroid autoimmune revealed a statistically significant link between triglycerides levels and the presence of thyroid autoimmunity (IVW analysis, OR = 0.603, 95%CI = 0.45 -0.807, P = 6.82E-04). The reverse analysis did not reveal any causal relationship between thyroid autoimmunity and MetS, including its five components.

Conclusions:

We have presented new genetic evidence demonstrating that MetS and its triglyceride components may serve as potential protective factors against thyroid autoimmunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza