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Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers.
Bukato, Katarzyna; Kostrzewa, Tomasz; Gammazza, Antonella Marino; Gorska-Ponikowska, Magdalena; Sawicki, Sambor.
Afiliación
  • Bukato K; Department of Obstetrics and Gynecology, Oncological Gynecology and Gynecological Endocrinology, Medical University of Gdansk, Smoluchowskiego 17, Gdansk, 80-214, Poland.
  • Kostrzewa T; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Debinki 1, Gdansk, 80-211, Poland.
  • Gammazza AM; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, 90127, Italy.
  • Gorska-Ponikowska M; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Debinki 1, Gdansk, 80-211, Poland. magdalena.gorska-ponikowska@gumed.edu.pl.
  • Sawicki S; IEMEST Istituto Euro-Mediterraneo di Scienza e Tecnologia, Palermo, 90127, Italy. magdalena.gorska-ponikowska@gumed.edu.pl.
Cell Commun Signal ; 22(1): 205, 2024 Apr 02.
Article en En | MEDLINE | ID: mdl-38566107
ABSTRACT

BACKGROUND:

Endometrial cancer is the most common gynecologic malignancy found in developed countries. Because therapy can be curative at first, early detection and diagnosis are crucial for successful treatment. Early diagnosis allows patients to avoid radical therapies and offers conservative management options. There are currently no proven biomarkers that predict the risk of disease occurrence, enable early identification or support prognostic evaluation. Consequently, there is increasing interest in discovering sensitive and specific biomarkers for the detection of endometrial cancer using noninvasive approaches. CONTENT Hormonal imbalance caused by unopposed estrogen affects the expression of genes involved in cell proliferation and apoptosis, which can lead to uncontrolled cell growth and carcinogenesis. In addition, due to their ability to cause oxidative stress, estradiol metabolites have both carcinogenic and anticarcinogenic properties. Catechol estrogens are converted to reactive quinones, resulting in oxidative DNA damage that can initiate the carcinogenic process. The molecular anticancer mechanisms are still not fully understood, but it has been established that some estradiol metabolites generate reactive oxygen species and reactive nitrogen species, resulting in nitro-oxidative stress that causes cancer cell cycle arrest or cell death. Therefore, identifying biomarkers that reflect this hormonal imbalance and the presence of endometrial cancer in minimally invasive or noninvasive samples such as blood or urine could significantly improve early detection and treatment outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Endometriales Límite: Female / Humans Idioma: En Revista: Cell Commun Signal Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Endometriales Límite: Female / Humans Idioma: En Revista: Cell Commun Signal Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido