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Nicotinamide deficiency promotes imidacloprid resistance via activation of ROS/CncC signaling pathway-mediated UGT detoxification in Nilaparvata lugens.
Deng, Mengqing; Xiao, Tianxiang; Xu, Xiyue; Wang, Wenxiu; Yang, Zhiming; Lu, Kai.
Afiliación
  • Deng M; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
  • Xiao T; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
  • Xu X; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
  • Wang W; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
  • Yang Z; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
  • Lu K; Anhui Province Key Laboratory of Crop Integrated Pest Management, Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China. Electronic address: lukai@ahau.edu.cn.
Sci Total Environ ; 926: 172035, 2024 May 20.
Article en En | MEDLINE | ID: mdl-38565349
ABSTRACT
Metabolic alternation is a typical characteristic of insecticide resistance in insects. However, mechanisms underlying metabolic alternation and how altered metabolism in turn affects insecticide resistance are largely unknown. Here, we report that nicotinamide levels are decreased in the imidacloprid-resistant strain of Nilaparvata lugens, may due to reduced abundance of the symbiotic bacteria Arsenophonus. Importantly, the low levels of nicotinamide promote imidacloprid resistance via metabolic detoxification alternation, including elevations in UDP-glycosyltransferase enzymatic activity and enhancements in UGT386B2-mediated metabolism capability. Mechanistically, nicotinamide suppresses transcriptional regulatory activities of cap 'n' collar isoform C (CncC) and its partner small muscle aponeurosis fibromatosis isoform K (MafK) by scavenging the reactive oxygen species (ROS) and blocking the DNA binding domain of MafK. In imidacloprid-resistant N. lugens, nicotinamide deficiency re-activates the ROS/CncC signaling pathway to provoke UGT386B2 overexpression, thereby promoting imidacloprid detoxification. Thus, nicotinamide metabolism represents a promising target to counteract imidacloprid resistance in N. lugens.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemípteros / Insecticidas Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemípteros / Insecticidas Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos