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The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose-response meta-analysis of randomized clinical trials.
Jalili, Farnaz; Moradi, Sajjad; Talebi, Sepide; Mehrabani, Sanaz; Ghoreishy, Seyed Mojtaba; Wong, Alexei; Jalalvand, Ali R; Kermani, Mohammad Ali Hojjati; Jalili, Cyrus; Jalili, Faramarz.
Afiliación
  • Jalili F; University of Adelaide Faculty of Medicine, Adelide, Australia.
  • Moradi S; Department of Nutrition and Food Sciences, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran.
  • Talebi S; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
  • Mehrabani S; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Ghoreishy SM; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Wong A; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Jalalvand AR; Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Kermani MAH; Department of Health and Human Performance, Marymount University, School of Health Sciences, Arlington, Virginia, USA.
  • Jalili C; Research Center of Oils and Fats, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Jalili F; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytother Res ; 38(6): 2847-2859, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38561995
ABSTRACT
The present systematic review and dose-response meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of citrus flavonoids supplementation (CFS) on endothelial function. Relevant RCTs were identified through comprehensive searches of the PubMed, ISI Web of Science, and Scopus databases up to May 30, 2023. Weighted mean differences and their corresponding 95% confidence intervals (CI) were pooled utilizing a random-effects model. A total of eight eligible RCTs, comprising 596 participants, were included in the analysis. The pooled data demonstrated a statistically significant augmentation in flow-mediated vasodilation (FMD) (2.75%; 95% CI 1.29, 4.20; I2 = 87.3%; p < 0.001) associated with CFS compared to the placebo group. Furthermore, the linear dose-response analysis indicated that each increment of 200 mg/d in CFS led to an increase of 1.09% in FMD (95% CI 0.70, 1.48; I2 = 94.5%; p < 0.001). The findings from the nonlinear dose-response analysis also revealed a linear relationship between CFS and FMD (Pnon-linearity = 0.903, Pdose-response <0.001). Our findings suggest that CFS enhances endothelial function. However, more extensive RTCs encompassing longer intervention durations and different populations are warranted to establish more precise conclusions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Flavonoides / Endotelio Vascular / Ensayos Clínicos Controlados Aleatorios como Asunto / Citrus / Suplementos Dietéticos Límite: Humans Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Flavonoides / Endotelio Vascular / Ensayos Clínicos Controlados Aleatorios como Asunto / Citrus / Suplementos Dietéticos Límite: Humans Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido