Your browser doesn't support javascript.
loading
Air Pollutants and Mortality Risk in Patients with Aortic Dissection: Evidence from a Clinical Cohort, Single-Cell Sequencing, and Proteomics.
Lin, Mengyue; Yan, Jingyi; Tang, Junshuang; Han, Sirui; Guo, Pi; Wu, Shiwan; Tao, Liang; Xiao, Hongyan; Chen, Yequn; Tan, Xuerui.
Afiliación
  • Lin M; Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
  • Yan J; Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
  • Tang J; Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
  • Han S; Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
  • Guo P; Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
  • Wu S; Department of Preventive Medicine, Shantou University Medical College, No. 22 Xinling Road, Shantou 515000, China.
  • Tao L; Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
  • Xiao H; Department of Cardiac Surgery, Wuhan Asia Heart Hospital Affiliated with Wuhan University of Science and Technology, No. 753 Jinghan Road, Wuhan 430000, China.
  • Chen Y; Department of Cardiac Surgery, Wuhan Asia Heart Hospital Affiliated with Wuhan University of Science and Technology, No. 753 Jinghan Road, Wuhan 430000, China.
  • Tan X; Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515000, China.
Environ Sci Technol ; 58(15): 6509-6518, 2024 Apr 16.
Article en En | MEDLINE | ID: mdl-38561599
ABSTRACT
We aimed to evaluate the association between air pollutants and mortality risk in patients with acute aortic dissection (AAD) in a longitudinal cohort and to explore the potential mechanisms of adverse prognosis induced by fine particulate matter (PM2.5). Air pollutants data, including PM2.5, PM10.0, nitrogen dioxide (NO2), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3), were collected from official monitoring stations, and multivariable Cox regression models were applied. Single-cell sequencing and proteomics of aortic tissue were conducted to explore the potential mechanisms. In total, 1,267 patients with AAD were included. Exposure to higher concentrations of air pollutants was independently associated with an increased mortality risk. The high-PM2.5 group carried approximately 2 times increased mortality risk. There were linear associations of PM10, NO2, CO, and SO2 exposures with long-term mortality risk. Single-cell sequencing revealed an increase in mast cells in aortic tissue in the high-PM2.5 exposure group. Enrichment analysis of the differentially expressed genes identified the inflammatory response as one of the main pathways, with IL-17 and TNF signaling pathways being among the top pathways. Analysis of proteomics also identified these pathways. This study suggests that exposure to higher PM2.5, PM10, NO2, CO, and SO2 are associated with increased mortality risk in patients with AAD. PM2.5-related activation and degranulation of mast cells may be involved in this process.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Contaminantes Atmosféricos / Contaminación del Aire / Disección Aórtica Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Contaminantes Atmosféricos / Contaminación del Aire / Disección Aórtica Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos