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Clusters of adipose tissue dysfunction in adults with type 2 diabetes identify those with worse lipidomic profile despite similar glycaemic control.
Della Pepa, Giuseppe; Carli, Fabrizia; Sabatini, Silvia; Pezzica, Samantha; Russo, Marco; Vitale, Marilena; Masulli, Maria; Riccardi, Gabriele; Rivellese, Angela A; Vaccaro, Olga; Bozzetto, Lutgarda; Gastaldelli, Amalia.
Afiliación
  • Della Pepa G; Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council-CNR, Pisa, Italy.
  • Carli F; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • Sabatini S; Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council-CNR, Pisa, Italy.
  • Pezzica S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Russo M; Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council-CNR, Pisa, Italy.
  • Vitale M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Masulli M; Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council-CNR, Pisa, Italy.
  • Riccardi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Rivellese AA; Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council-CNR, Pisa, Italy.
  • Vaccaro O; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Bozzetto L; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • Gastaldelli A; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Diabetes Metab Res Rev ; 40(4): e3798, 2024 May.
Article en En | MEDLINE | ID: mdl-38558269
ABSTRACT

AIMS:

To investigate clusters of adipose tissue dysfunction, that is, with adipose tissue insulin resistance (ADIPO-IR) and large waist circumference (WC), identify a worse lipidomic profile characterised by a high proportion of lipids rich in saturated fatty acids (SFA). MATERIALS AND

METHODS:

Hierarchical clustering based on WC and ADIPO-IR (calculated as fasting plasma non-esterified fatty acids times fasting plasma insulin, FFA×INS), was performed in 192 adults with overweight/obesity and type 2 diabetes (T2D) treated with metformin (HbA1c = 7.8%). Free fatty acid composition and lipidomic profile were measured by mass spectrometry (GC-MS and LC-MSQTOF). Indexes of fatty acid desaturation (stearoyl-coA desaturase-1 activity, SCD116 = palmitoleic acid/palmitic acid and SCD118 = oleic acid/stearic acid) and of insulin resistance (HOMA-IR) were also calculated.

RESULTS:

Three clusters were identified CL1 (ADIPO-IR = 4.9 ± 2.4 and WC = 96±7 cm, mean ± SD), CL2 (ADIPO-IR = 6.5 ± 2.5 and WC = 114 ± 7 cm), and CL3 (ADIPO-IR = 15.0 ± 4.7 and WC = 107 ± 8 cm). Insulin concentrations, ADIPO-IR, and HOMA-IR significantly increased from CL1 to CL3 (all p < 0.001), while fasting glucose concentrations, HbA1c, dietary lipids and caloric intake were similar. Moreover, CL3 showed significantly higher concentrations of monounsaturated free fatty acids, oleic and palmitoleic acids, triglycerides (TAG) rich in saturated FA and associated with de novo lipogenesis (i.e., TAG 46-50), higher SCD116, SCD118, ceramide (d180/180), and phosphatidylcholine aa(365) compared with CL1/CL2 (all p < 0.005).

CONCLUSIONS:

High ADIPO-IR and large WC identify a worse lipid profile in T2D characterised by complex lipids rich in SFA, likely due to de novo synthesis given higher plasma monounsaturated FFA and increased desaturase activity indexes. REGISTRATION NUMBER TRIAL ID NCT00700856 https//clinicaltrials.gov.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Diabetes Mellitus Tipo 2 Límite: Adult / Humans Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Diabetes Mellitus Tipo 2 Límite: Adult / Humans Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido