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The risk of COVID-19 in Cushing's disease is independently related to disease activity (hypercortisolism) and obesity.
M G Mascarenhas-Nakano, Bruna; R Correa-Silva, Silvia; Fracacio, Silvia M R; W Brock, Paola; F Dias, Rossella; Binda, Eduarda S S; Santos-Neto, Pedro F; Portari, Luiz H C; Sanudo, Adriana; Abucham, Julio.
Afiliación
  • M G Mascarenhas-Nakano B; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • R Correa-Silva S; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil, dra.silviaregina@terra.com.br.
  • Fracacio SMR; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • W Brock P; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • F Dias R; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Binda ESS; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Santos-Neto PF; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Portari LHC; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Sanudo A; Departamento de Medicina Preventiva, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Abucham J; Unidade de Neuroendocrinologia, Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
Arch Endocrinol Metab ; 68: e220313, 2024 Mar 27.
Article en En | MEDLINE | ID: mdl-38557479
ABSTRACT

Objective:

To evaluate the cumulative incidence, risk factors, and outcomes of COVID-19 in patients with Cushing's disease (CD). Subjects and

methods:

In all, 60 patients with CD following up in our outpatient clinic answered via phone interview a questionnaire about the occurrence of COVID-19 infection documented by RT-PCR (including the diagnosis date and clinical outcome) and vaccination status. Clinical and biochemical data on disease activity (hypercortisolism) and comorbidities (obesity, diabetes mellitus, and hypertension) were obtained from the patients' electronic medical records. Risk ratios (RRs) of risk factors were obtained using univariate and multivariate analyses.

Results:

The cumulative incidence of COVID-19 in patients with CD during the observation period was 31.7%, which was higher than that in the general reference population (9.5%). The cumulative incidence of COVID-19 was significantly higher in patients with hypercortisolism (57% versus 17% in those without hypercortisolism, p = 0.012) and obesity (54% versus 9% in those without obesity, p < 0.001) but not in patients with hypertension or diabetes mellitus. On multivariate analysis, hypercortisolism and obesity were each independent risk factors for COVID-19 (RR 2.18, 95% CI 1.06-4.46, p = 0.033 and RR 5.19, 95% CI 1.61-16.74, p = 0.006, respectively).

Conclusion:

The incidence of COVID-19 in patients with CD was associated with hypercortisolism, as expected, and obesity, a novel and unexpected finding. Thus, correction of hypercortisolism and obesity should be implemented in patients with CD during the current and future COVID-19 outbreaks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Cushing / Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT) / Diabetes Mellitus / COVID-19 / Hipertensión Límite: Humans Idioma: En Revista: Arch Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Cushing / Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT) / Diabetes Mellitus / COVID-19 / Hipertensión Límite: Humans Idioma: En Revista: Arch Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil