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Evaluation of biological selenium nanoparticles on growth performance, histopathology of vital organs and genotoxicity in Japanese quails (coturnix coturnix japonica).
Naz, Shabana; Bibi, Gulnaz; Nadeem, Rida; A Alhidary, Ibrahim; Dai, Sifa; Israr, Muhammad; Ullah Khan, Rifat.
Afiliación
  • Naz S; Department of Zoology, Government College University, Faisalabad, Pakistan.
  • Bibi G; Department of Zoology, Government College University, Faisalabad, Pakistan.
  • Nadeem R; Department of Zoology, Government College University, Faisalabad, Pakistan.
  • A Alhidary I; Department of Animal Production, College of Food and Agriculture, King Saud University, Riadh, Saudi Arabia.
  • Dai S; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang City, Jingxi province, P.R. China.
  • Israr M; College of Veterinary Sciences, The Univeristy of Agriculture, Peshawar, Pakistan.
  • Ullah Khan R; College of Veterinary Sciences, The Univeristy of Agriculture, Peshawar, Pakistan.
Vet Q ; 44(1): 1-10, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38557294
ABSTRACT
Research on the effects of selenium nanoparticles (Se-NPs), particularly in Japanese quails, is lacking, especially regarding the potential for DNA damage. Therefore, this study aimed to investigate the impact of administering 0.2 and 0.4 mg/kg of Se-NPs on the growth performance, DNA integrity, and histopathological alterations of the liver, lung, kidney, and heart in quails. A total of 480 one-day-old Japanese quails were divided into three experimental groups as follows Group 1 served as the control and received only basic feed, while Group 2 and 3 received 0.2 mg/kg and 0.4 mg/kg of Se-NPs via oral gavage. Our results suggested that, birds fed with Se-NPs at both levels significantly (p < .01) reduced feed intake, however, weight gain was significantly (p < .01) increased in quails supplemented with 0.2 mg/kg. Similarly, feed conversion ratio (FCR) was significantly (p < .01) reduced in group supplemented with 0.2 mg/kg Se-NPs. White blood cells increased significantly (P0.01) in 0.4 mg/kg while haemoglobin and red cell distribution width decreased (p < .01) in the same group. Both treatment regimens resulted in DNA damage and histopathological alterations; however, the adverse effects were more prominent in the group receiving the higher dose of 0.4 mg/kg. These findings indicate that the lower dose of 0.2 mg/kg may have beneficial effects on growth. However, the higher dose of 0.4 mg/kg not only negatively impacts growth but also leads to histopathological alterations in major organs of the body and DNA damage as well.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Coturnix Límite: Animals Idioma: En Revista: Vet Q Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Coturnix Límite: Animals Idioma: En Revista: Vet Q Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido