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Environmental exposure to melamine and its derivatives and kidney outcomes in children.
Day, Drew B; Melough, Melissa M; Flynn, Joseph T; Zhu, Hongkai; Kannan, Kurunthachalam; Ruzinski, John; de Boer, Ian H; Sathyanarayana, Sheela.
Afiliación
  • Day DB; Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, WA, 98101, USA. Electronic address: drew.day@seattlechildrens.org.
  • Melough MM; Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE, 19713, USA. Electronic address: melough@udel.edu.
  • Flynn JT; Division of Nephrology, Seattle Children's Hospital, 4800 Sand Point NE, Seattle, WA, 98105, USA; Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Seattle, WA, 98195, USA. Electronic address: joseph.flynn@seattlechildrens.org.
  • Zhu H; Department of Environmental Medicine, Nankai University, No. 38 Tongyan Road, Jinnan District, Tianjin, 300350, China. Electronic address: zhuhongkai@nankai.edu.cn.
  • Kannan K; Wadsworth Center, New York State Department of Health, Albany, NY 12237, USA. Electronic address: Kurunthachalam.kannan@health.ny.gov.
  • Ruzinski J; Kidney Research Institute, Department of Nephrology, University of Washington, 908 Jefferson St, Seattle, WA, 98104, USA. Electronic address: Jruzinski@Nephrology.washington.edu.
  • de Boer IH; Kidney Research Institute, Department of Nephrology, University of Washington, 908 Jefferson St, Seattle, WA, 98104, USA. Electronic address: IdeBoer@Nephrology.washington.edu.
  • Sathyanarayana S; Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, WA, 98101, USA; Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Seattle, WA, 98195, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.o
Environ Res ; 252(Pt 1): 118789, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38555096
ABSTRACT
Melamine caused acute nephrotoxicity in a past food adulteration incident, but it is unclear whether and how widespread ambient exposure to melamine and related compounds might affect pediatric kidney health. We assessed cross-sectional associations between childhood exposure to melamine and its derivatives and biomarkers of kidney injury and health and explored potential heterogeneity by sex suggested by sex-dependent differences in renal physiology. We measured melamine and its derivatives ammeline, ammelide, and cyanuric acid (CYA) in spot urine samples collected from 192 children from an urban site (Seattle, WA) and 187 children from a rural site (Yakima, WA) aged 4-8 years in the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) Study. In addition, biomarkers of kidney injury were measured in the same urine samples, including albumin, total protein, KIM-1, NAG, NGAL, and EGF. We utilized linear regressions to examine associations between individual chemical exposures and kidney biomarkers. Interaction terms examined association modification by sex, as well as potential interactions between melamine and CYA. Despite comparable exposures, girls had higher levels of many kidney injury biomarkers compared to boys. A ten-fold higher melamine concentration was associated with a 18% (95% CI 5.6%, 31%) higher EGF in the full sample, while ten-fold higher melamine was associated with a 76% (14.1%, 173%) higher KIM-1 in boys but not in girls (-10.1% (-40.6%, 36.1%), interaction p = 0.026). Melamine exhibited significant negative interactions with CYA in association with total protein and NAG that appeared to be specific to girls. Our results suggest possible associations between melamine exposure and markers of kidney injury that may be more pronounced in boys. These findings provide novel insights into melamine and related derivative compound health effects at low levels of exposure in children and emphasize the role of sex in mediating the relationship between nephrotoxicant exposure and kidney injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Biomarcadores / Exposición a Riesgos Ambientales Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Biomarcadores / Exposición a Riesgos Ambientales Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos