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Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells.
Gu, Weihong; Eke, Chino; Gonzalez Santiago, Eduardo; Olaloye, Oluwabunmi; Konnikova, Liza.
Afiliación
  • Gu W; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
  • Eke C; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
  • Gonzalez Santiago E; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
  • Olaloye O; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
  • Konnikova L; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA; Program in Tra
Mucosal Immunol ; 17(4): 599-617, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38555026
ABSTRACT
Proper development of mucosal immunity is critical for human health. Over the past decade, it has become evident that in humans, this process begins in utero. However, there are limited data on the unique features and functions of fetal mucosal immune cells. To address this gap, we integrated several single-cell ribonucleic acid sequencing datasets of the human small intestine (SI) to create an SI transcriptional atlas throughout the human life span, ranging from the first trimester to adulthood, with a focus on immune cells. Fetal SI displayed a complex immune landscape comprising innate and adaptive immune cells that exhibited distinct transcriptional programs from postnatal samples, especially compared with pediatric and adult samples. We identified shifts in myeloid populations across gestation and progression of memory T-cell states throughout the human lifespan. In particular, there was a marked shift of memory T cells from those with stem-like properties in the fetal samples to fully differentiated cells with a high expression of activation and effector function genes in adult samples, with neonatal samples containing both features. Finally, we demonstrate that the SI developmental atlas can be used to elucidate improper trajectories linked to mucosal diseases by implicating developmental abnormalities underlying necrotizing enterocolitis, a severe intestinal complication of prematurity. Collectively, our data provide valuable resources and important insights into intestinal immunity that will facilitate regenerative medicine and disease understanding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis de la Célula Individual / Feto / Intestino Delgado Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis de la Célula Individual / Feto / Intestino Delgado Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos