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Invasive Nodal Staging via Endobronchial Ultrasound and Outcome in Patients Treated with Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer - Results from a Single Institution Study.
George, Benjamin; Baydoun, Atallah; Bhat, Samar; Bailey, Lauryn; Arsenault, Theodore; Sun, Yilun; Zhang, Yuxia; Zheng, Yiran; Vempati, Prashant; Podder, Tarun; Biswas, Tithi.
Afiliación
  • George B; School of Medicine, Case Western Reserve University, Cleveland, OH.
  • Baydoun A; University Hospitals, Seidman Cancer Center, Cleveland, OH.
  • Bhat S; School of Medicine, Case Western Reserve University, Cleveland, OH.
  • Bailey L; School of Medicine, Case Western Reserve University, Cleveland, OH.
  • Arsenault T; University Hospitals, Seidman Cancer Center, Cleveland, OH; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
  • Sun Y; School of Medicine, Case Western Reserve University, Cleveland, OH.
  • Zhang Y; University Hospitals, Seidman Cancer Center, Cleveland, OH.
  • Zheng Y; School of Medicine, Case Western Reserve University, Cleveland, OH; University Hospitals, Seidman Cancer Center, Cleveland, OH.
  • Vempati P; School of Medicine, Case Western Reserve University, Cleveland, OH; University Hospitals, Seidman Cancer Center, Cleveland, OH.
  • Podder T; School of Medicine, Case Western Reserve University, Cleveland, OH; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
  • Biswas T; School of Medicine, Case Western Reserve University, Cleveland, OH; University Hospitals, Seidman Cancer Center, Cleveland, OH; MetroHealth, Cleveland, OH. Electronic address: tithipodder@gmail.com.
Clin Lung Cancer ; 25(4): e181-e188, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38553326
ABSTRACT

INTRODUCTION:

Stereotactic body radiation therapy (SBRT) is an effective treatment for medically inoperable early-stage non-small cell lung cancer (NSCLC). The prognostic value of invasive nodal staging (INS) for patients undergoing SRBT has not been studied extensively. Herein, we report the impact of INS in addition to 18F-FDG-PET on treatment outcome for patients with NSCLC undergoing SBRT. MATERIALS AND

METHODS:

Patients with stage I/ II NSCLC who underwent SBRT were included with IRB approval. Clinical, dosimetric, and radiological data were obtained. Overall survival (OS), regional recurrence free survival (RRFS), local recurrence free survival (LRFS), and distant recurrence free survival (DRFS) were analyzed using Kaplan Meyer method. Univariable analysis (UVA) and multivariable analysis (MVA) were performed to assess the relationship between the variables and the outcomes.

RESULTS:

A total of 376 patients were included in the analysis. Median follow up was 43 months (IQ 32.6-45.8). Median OS, LRFS, RRFS, DRFS were 40, 32, 32, 33 months, respectively. The 5-year local, regional, and distant failure rates were 13.4%, 23.5% and 25.3%, respectively. The 1-year, 3-year and 5-year OS were 83.8%, 55.6%, and 36.3%, respectively. On MVA, INS was not a predictor of either improved overall or any recurrence free survival endpoints while larger tumor size, age, and adjusted Charleston co-morbidity index (aCCI) were significant for inferior LRFS, RRFS, and DRFS.

CONCLUSION:

Invasive nodal staging did not improve overall or recurrence free survival among patients with early-stage NSCLC treated with SBRT whereas older age, aCCI, and larger tumor size were significant predictors of LRFS, RRFS, and DRFS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiocirugia / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Estadificación de Neoplasias Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiocirugia / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Estadificación de Neoplasias Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos