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In situ fabricated ZnO nanostructures within carboxymethyl cellulose-based ternary hydrogels for wound healing applications.
Palem, Ramasubba Reddy; Kim, Byoung Ju; Baek, Inho; Choi, Hyejong; Suneetha, Maduru; Shimoga, Ganesh; Lee, Soo-Hong.
Afiliación
  • Palem RR; Department of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea.
  • Kim BJ; Department of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea.
  • Baek I; Department of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea.
  • Choi H; Department of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea.
  • Suneetha M; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea.
  • Shimoga G; Department of Biotechnology and Nanomedicine, SINTEF Industry, 7034 Trondheim, Norway.
  • Lee SH; Department of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea. Electronic address: lee.soohong@gmail.com.
Carbohydr Polym ; 334: 122020, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38553219
ABSTRACT
Zinc oxide nanostructures (ZnO NS) were fabricated in situ within a ternary hydrogel system composed of carboxymethyl cellulose-agarose-polyvinylpyrrolidone (CAP@ZnO TNCHs) by a one-pot method employing moist-heat solution casting. The percentages of CMC and ZnO NS were varied in the CAP hydrogel films and then they were investigated by different techniques, such as ATR/FTIR, TGA, XRD, XPS, and FE-SEM analysis. Furthermore, the mechanical properties, hydrophilicity, swelling, porosity, and antibacterial activity of the CAP@ZnO TNCHs were studied. In-vitro biocompatibility assays were performed with skin fibroblast (CCD-986sk) cells. In-vitro culture of CCD-986sk fibroblasts showed that the ZnO NS facilitated cell adhesion and proliferation. Furthermore, the application of CAP@ZnO TNCHs enhanced cellular interactions and physico-chemical, antibacterial bacterial, and biological performance relative to unmodified CAP hydrogels. Also, an in vivo wound healing study verified that the CAP@ZnO TNCHs promoted wound healing significantly within 18 days, an effect superior to that of unmodified CAP hydrogels. Hence, these newly developed cellulose-based ZnO TNCHs are promising materials for wound healing applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Nanoestructuras Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Nanoestructuras Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido