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Differentiation of confluent hepatic fibrosis and infiltrative hepatocellular carcinoma on MR imaging.
Liu, Jing-Jing; Duan, Meng-Jiao; Huang, Meng-Yue; Huang, Meng-Na; Wang, Meng-Zhu; Zhang, Yong; Cheng, Jing-Liang.
Afiliación
  • Liu JJ; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. liujingjing198631@126.com.
  • Duan MJ; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Huang MY; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Huang MN; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Wang MZ; MR Collaboration, Siemens Healthcare Ltd.,, Beijing, China.
  • Zhang Y; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Cheng JL; Department of MR Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Abdom Radiol (NY) ; 49(5): 1479-1488, 2024 05.
Article en En | MEDLINE | ID: mdl-38551668
ABSTRACT

BACKGROUND:

To identify reliable magnetic resonance imaging (MRI) features that can differentiate confluent fibrosis (CF) from infiltrative hepatocellular carcinoma (HCC).

METHODS:

A retrospective analysis was conducted on Twenty CF patients and 28 infiltrative HCC patients who underwent upper abdomen MRI scans. The imaging features of lesions were analyzed, and the apparent diffusion coefficient (ADC) of lesions were measured. Accuracy, sensitivity and specificity for the diagnosis of CF were calculated for each category individually and combined.

RESULTS:

Compared to infiltrative HCC, hepatic capsular retraction at the site of lesion, hepatic volume loss at the site of lesion and "nodular surround sign" were more common in patients with CF (all P < 0.001). Hepatic volume loss at the site of lesion, no or mild enhancement in arterial phase, and hyper-enhancing in delayed phase to the background parenchyma showed superior diagnostic accuracy (83.3%, 85.4%, 97.9%, respectively). When the lesion exhibited hepatic volume loss at the site of lesion or no or mild enhancement in arterial phase or hyper-enhancing in delayed phase, a sensitivity of 100.0% for the diagnosis of CF was achieved. When the lesion was positive for any two of three categories, or positive for all three categories, a specificity of 100.0% was achieved. The ADC values of CF were higher than those of infiltrative HCC (P < 0.001).

CONCLUSION:

The combination of the hepatic volume loss at the site of lesion, no or mild enhancement in arterial phase, and hyper-enhancing in delayed phase to the background parenchyma can be considered reliable MR features for the diagnosis of CF, as they allow differentiation from infiltrative HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Sensibilidad y Especificidad / Carcinoma Hepatocelular / Cirrosis Hepática / Neoplasias Hepáticas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Abdom Radiol (NY) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Sensibilidad y Especificidad / Carcinoma Hepatocelular / Cirrosis Hepática / Neoplasias Hepáticas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Abdom Radiol (NY) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos