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Trans-generational effects of parental exposure to drugs of abuse on offspring memory functions.
Riyahi, Javad; Taslimi, Zahra; Gelfo, Francesca; Petrosini, Laura; Haghparast, Abbas.
Afiliación
  • Riyahi J; Department of Cognitive and Behavioral Science and Technology in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.
  • Taslimi Z; Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Fertility and Infertility Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: za_t520@ymail.com.
  • Gelfo F; IRCCS Santa Lucia Foundation, Rome, Italy; Department of Human Sciences, Guglielmo Marconi University, Rome, Italy.
  • Petrosini L; IRCCS Santa Lucia Foundation, Rome, Italy.
  • Haghparast A; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran; Department of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran. Electronic addr
Neurosci Biobehav Rev ; 160: 105644, 2024 May.
Article en En | MEDLINE | ID: mdl-38548003
ABSTRACT
Recent evidence reported that parental-derived phenotypes can be passed on to the next generations. Within the inheritance of epigenetic characteristics allowing the transmission of information related to the ancestral environment to the offspring, the specific case of the trans-generational effects of parental drug addiction has been extensively studied. Drug addiction is a chronic disorder resulting from complex interactions among environmental, genetic, and drug-related factors. Repeated exposures to drugs induce epigenetic changes in the reward circuitry that in turn mediate enduring changes in brain function. Addictive drugs can exert their effects trans-generally and influence the offspring of addicted parents. Although there is growing evidence that shows a wide range of behavioral, physiological, and molecular phenotypes in inter-, multi-, and trans-generational studies, transmitted phenotypes often vary widely even within similar protocols. Given the breadth of literature findings, in the present review, we restricted our investigation to learning and memory performances, as examples of the offspring's complex behavioral outcomes following parental exposure to drugs of abuse, including morphine, cocaine, cannabinoids, nicotine, heroin, and alcohol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína / Trastornos Relacionados con Sustancias Límite: Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína / Trastornos Relacionados con Sustancias Límite: Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos