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Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension.
Fejes, Rebeka; Lutnik, Martin; Weisshaar, Stefan; Pilat, Nina; Wagner, Karl-Heinz; Stüger, Hans-Peter; Peake, Jonathan M; Woodman, Richard J; Croft, Kevin D; Bondonno, Catherine P; Hodgson, Jonathan M; Wolzt, Michael; Neubauer, Oliver.
Afiliación
  • Fejes R; Department of Nutritional Sciences, Research Platform Active Ageing, University of Vienna, Vienna, Austria. oliver.neubauer@univie.ac.at.
  • Lutnik M; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria.
  • Weisshaar S; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
  • Pilat N; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
  • Wagner KH; Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
  • Stüger HP; Department of Nutritional Sciences, Research Platform Active Ageing, University of Vienna, Vienna, Austria. oliver.neubauer@univie.ac.at.
  • Peake JM; Division Integrative Risk Assessment, Data and Statistics, Austrian Agency for Health and Food Safety, Vienna, Austria.
  • Woodman RJ; School of Biomedical Sciences, Queensland University of Technology, Queensland, Australia.
  • Croft KD; Flinders Centre for Epidemiology and Biostatistics, Flinders University, Adelaide, South Australia, Australia.
  • Bondonno CP; Medical School, University of Western Australia, Royal Perth Hospital Unit, Perth, Western Australia, Australia.
  • Hodgson JM; Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Royal Perth Hospital Research Foundation, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Wolzt M; Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Royal Perth Hospital Research Foundation, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Neubauer O; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Food Funct ; 15(8): 4065-4078, 2024 Apr 22.
Article en En | MEDLINE | ID: mdl-38546454
ABSTRACT
The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × âˆ¼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST). Measurements included nitrate and nitrite in plasma and saliva; endothelial-dependent and -independent forearm blood flow (FBF) responses to acetylcholine (FBFACh) and glyceryltrinitrate (FBFGTN); and clinic-, home- and 24-hour ambulatory blood pressure. Compared to placebo, plasma and salivary nitrate and nitrite increased at 3H and 4WK POST following nitrate treatment (P < 0.01), suggesting a functioning nitrate-nitrite-NO pathway in the participants of this study. There were no differences between treatments in FBFACh and FBFGTN-area under the curve (AUC) ratios [AUC ratios after (3H POST, 4WK POST) compared with before (PRE) the intervention], or 24-hour ambulatory blood pressure or home blood pressure measures (P > 0.05). These findings do not support the hypothesis that an increased intake of dietary nitrate exerts sustained beneficial effects on FBF or blood pressure in hypertensive older adults, providing important information on the efficacy of nitrate-based interventions for healthy vascular aging. This study was registered under ClinicialTrials.gov (NCT04584372).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Estudios Cruzados / Beta vulgaris / Jugos de Frutas y Vegetales / Hipertensión / Nitratos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Food Funct Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Estudios Cruzados / Beta vulgaris / Jugos de Frutas y Vegetales / Hipertensión / Nitratos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Food Funct Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido