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Cutaneous Calcium/Calmodulin-Dependent Protein Kinase II-γ-Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis.
Yu, Yafen; Chen, Weiwei; Li, Bao; Li, Zhuo; Wang, Yirui; Mao, Yiwen; Fan, Wencheng; Bai, Yuanming; Hu, Hongbo; Zhen, Qi; Sun, Liangdan.
Afiliación
  • Yu Y; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
  • Chen W; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
  • Li B; The Center for Scientific Research, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
  • Li Z; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
  • Wang Y; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
  • Mao Y; The Comprehensive Lab, College of Basic, Anhui Medical University, Hefei, 230032, China.
  • Fan W; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
  • Bai Y; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
  • Hu H; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
  • Zhen Q; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
  • Sun L; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
Adv Sci (Weinh) ; 11(23): e2306772, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38544478
ABSTRACT
Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It is found that cutaneous calcium/calmodulin-dependent protein kinase II-γ (CAMK2γ), expressed mainly in sympathetic nerves, is activated by stress and imiquimod in mouse skin. Camk2g-deficient mice exhibits attenuated imiquimod-induced psoriasis-like manifestations and skin inflammation. CaMK2γ regulates dermal γδT-cell interleukin-17 production in imiquimod-treated mice, dependent on norepinephrine production following cutaneous sympathetic nerve activation. Adrenoceptor ß1, the primary skin norepinephrine receptor, colocalises with γδT cells. CaMK2γ aggravates psoriasiform inflammation via sympathetic nerve-norepinephrine-γδT cell-adrenoceptor ß1-nuclear factor-κB and -p38 axis activation. Application of alcaftadine, a small-molecule CaMK2γ inhibitor, relieves imiquimod-induced psoriasis-like manifestations in mice. This study reveals the mechanisms of sympathetic-nervous-system regulation of γδT-cell interleukin-17 secretion, and provides insight into neuropsychiatric factors dictating psoriasis pathogenesis and new potential targets for clinical psoriasis treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Sistema Nervioso Simpático / Norepinefrina / Modelos Animales de Enfermedad Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Sistema Nervioso Simpático / Norepinefrina / Modelos Animales de Enfermedad Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania