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Evaluation of Two Vaccines against Foot-and-Mouth Disease Used in Transcaucasian Countries by Small-Scale Immunogenicity Studies Conducted in Georgia, Azerbaijan and Armenia.
Foglia, Efrem Alessandro; Chaligava, Tengiz; Aliyeva, Tamilla; Kharatyan, Satenik; Tranquillo, Vito; Pötzsch, Carsten; van Maanen, Cornelis; Rosso, Fabrizio; Grazioli, Santina; Brocchi, Emiliana.
Afiliación
  • Foglia EA; Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
  • Chaligava T; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), FAO, 00100 Rome, Italy.
  • Aliyeva T; National Food Agency (NFA) of the Ministry of Environmental Protection and Agriculture (MEPA), Tbilisi 0159, Georgia.
  • Kharatyan S; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), FAO, 00100 Rome, Italy.
  • Tranquillo V; Azerbaijan Food Safety Institute (AFSI) at the Azerbaijan Food Safety Agency (AFSA), Baku 1069, Azerbaijan.
  • Pötzsch C; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), FAO, 00100 Rome, Italy.
  • van Maanen C; Scientific Center for Risks Assessment and Analysis in Food Safety Area-CJCS of Republic of Armenia, Yerevan 0071, Armenia.
  • Rosso F; Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
  • Grazioli S; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), FAO, 00100 Rome, Italy.
  • Brocchi E; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), FAO, 00100 Rome, Italy.
Vaccines (Basel) ; 12(3)2024 Mar 12.
Article en En | MEDLINE | ID: mdl-38543929
ABSTRACT
In countries endemic for foot-and-mouth disease (FMD), routine or emergency vaccinations are strategic tools to control the infection. According to the WOAH/FAO guidelines, a prior estimation of vaccine effectiveness is recommendable to optimize control programs. This study reports the results of a small-scale immunogenicity study performed in Transcaucasian Countries. Polyvalent vaccines, including FMDV serotypes O, A (two topotypes) and Asia1 from two different manufacturers, were evaluated in Georgia, Azerbaijan and Armenia. Naïve large and small ruminants were vaccinated once and a subgroup received a second booster dose. The titers of neutralizing antibodies in sera collected sequentially up to 180 DPV were determined through the Virus Neutralization Test versus homologous strains. This study led to the estimate that both the vaccines evaluated will not induce a protective and long-lasting population immunity, even after a second vaccination, stressing that consecutive administrations of both vaccines every three months are mandatory if one aspires to achieve protective herd immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza