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The Causality between Human Immunoglobulin G (IgG) N-Glycosylation and Aging: A Mendelian Randomization Study.
Sun, Wenxin; Jian, Xuening; Zhang, Jie; Meng, Xiaoni; Wang, Haotian; Zheng, Deqiang; Wu, Lijuan; Wang, Youxin.
Afiliación
  • Sun W; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Jian X; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Zhang J; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Meng X; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Wang H; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Zheng D; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Wu L; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Wang Y; Beijing Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China.
Molecules ; 29(6)2024 Mar 14.
Article en En | MEDLINE | ID: mdl-38542917
ABSTRACT

BACKGROUND:

Immunoglobulin G (IgG) N-glycosylation is considered a potential biomarker for aging and various pathological conditions. However, whether these changes in IgG N-glycosylation are a consequence or a contributor to the aging process remains unclear. This study aims to investigate the causality between IgG N-glycosylation and aging using Mendelian randomization (MR) analysis.

METHODS:

We utilized genetic variants associated with IgG N-glycosylation traits, the frailty index (FI), and leukocyte telomere length (LTL) from a previous genome-wide association study (GWAS) on individuals of European ancestry. Two-sample and multivariable MR analyses were conducted, employing the inverse-variance weighted (IVW) method. Sensitivity analyses were performed to assess potential confounding factors.

RESULTS:

Using the IVW method, we found suggestive evidence of a causal association between GP14 and FI (ß 0.026, 95% CI 0.003 to 0.050, p = 0.027) and LTL (ß -0.020, 95% CI -0.037 to -0.002, p = 0.029) in the two-sample MR analysis. In the multivariable MR analysis, suggestive evidence was found for GP23 and FI (ß -0.119, 95% CI -0.219 to -0.019, p = 0.019) and GP2 and LTL (ß 0.140, 95% CI 0.020 to 0.260, p = 0.023).

CONCLUSIONS:

In conclusion, our results supported a potentially causal effect of lower GP23 levels on an advanced aging state. Additional verification is required to further substantiate the causal relationship between glycosylation and aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza