Your browser doesn't support javascript.
loading
Waist Circumference and Body Mass Index as Predictors of Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
Giannopapas, Vasileios; Stefanou, Maria-Ioanna; Smyrni, Vassiliki; Kitsos, Dimitrios K; Kosmidou, Maria; Stasi, Sophia; Chasiotis, Athanasios K; Stavrogianni, Konstantina; Papagiannopoulou, Georgia; Tzartos, John S; Paraskevas, George P; Tsivgoulis, Georgios; Giannopoulos, Sotirios.
Afiliación
  • Giannopapas V; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Stefanou MI; Laboratory of Neuromuscular and Cardiovascular Study of Motion, University of West Attica, 12243 Aigaleo, Greece.
  • Smyrni V; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Kitsos DK; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Kosmidou M; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Stasi S; Department of Internal Medicine, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece.
  • Chasiotis AK; Biomechanics Laboratory, Department of Physiotherapy, University of Peloponnese, 23100 Sparta, Greece.
  • Stavrogianni K; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Papagiannopoulou G; Laboratory of Neuromuscular and Cardiovascular Study of Motion, University of West Attica, 12243 Aigaleo, Greece.
  • Tzartos JS; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Paraskevas GP; Department of Physiology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece.
  • Tsivgoulis G; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
  • Giannopoulos S; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
J Clin Med ; 13(6)2024 Mar 18.
Article en En | MEDLINE | ID: mdl-38541964
ABSTRACT

Background:

While obesity has been shown to elevate the risk of developing multiple sclerosis (MS), there is a lack of strong evidence regarding its role in the disability progression and status of MS patients.

Methods:

This systematic review and meta-analysis aimed to provide comparative estimates of WC and BMI in patients with MS (PwMS) and to investigate potential associations between the waist circumference (WC) and body mass index (BMI) and demographic and specific MS characteristics. Adhering to PRISMA guidelines, a detailed search of the MEDLINE PubMed, Cochrane Library, and Scopus databases was conducted.

Results:

A total of 16 studies were included. The pooled mean WC and BMI among PwMS was estimated to be 87.27 cm (95%CI [84.07; 90.47]) and 25.73 (95%CI [25.15; 26.31]), respectively. Meta-regression models established a significant bidirectional relationship between WC and the Expanded Disability Scale (EDSS) (p < 0.001) but not between BMI and EDSS (p = 0.45). Sensitivity analyses showed no association between WC and age (p = 0.48) and a tendency between WC and disease duration (p = 0.08).

Conclusions:

Although WC measurements classify PwMS as normal weight, BMI measurements classify them as overweight. Therefore, WC should complement BMI evaluations in clinical practice. Additionally, our findings highlight the significant association between abdominal fat, as indicated by WC, and disease progression. Considering the heightened risk of cardiovascular comorbidity and mortality among PwMS, we recommend integrating both WC and BMI as standard anthropometric measurements in routine clinical examinations and targeted prevention strategies for PwMS.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza