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Extracellular Vesicles as Next-Generation Biomarkers in Lung Cancer Patients: A Case Report on Adenocarcinoma and Squamous Cell Carcinoma.
Ruzycka-Ayoush, Monika; Prochorec-Sobieszek, Monika; Cieszanowski, Andrzej; Glogowski, Maciej; Szumera-Cieckiewicz, Anna; Podgorska, Joanna; Targonska, Alicja; Sobczak, Kamil; Mosieniak, Grazyna; Grudzinski, Ireneusz P.
Afiliación
  • Ruzycka-Ayoush M; Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
  • Prochorec-Sobieszek M; Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena Str. 5, 02-781 Warsaw, Poland.
  • Cieszanowski A; Department of Clinical Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena Str. 5, 02-781 Warsaw, Poland.
  • Glogowski M; Department of Lung Cancer and Chest Tumors, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena Str. 5, 02-781 Warsaw, Poland.
  • Szumera-Cieckiewicz A; Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena Str. 5, 02-781 Warsaw, Poland.
  • Podgorska J; Department of Clinical Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena Str. 5, 02-781 Warsaw, Poland.
  • Targonska A; Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
  • Sobczak K; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Mosieniak G; Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
  • Grudzinski IP; Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Life (Basel) ; 14(3)2024 Mar 20.
Article en En | MEDLINE | ID: mdl-38541732
ABSTRACT
Extracellular vesicles (EVs) released from primary cell lines, originating from resected tissues during biopsies in patients with non-small cell lung cancer (NSCLC) revealing adenocarcinoma and squamous cell carcinoma subtypes, were examined for membrane proteomic fingerprints using a proximity barcoding assay. All the collected EVs expressed canonical tetraspanins (CD9, CD63, and CD81) highly coexpressed with molecules such as lysosome-associated membrane protein-1 (LAMP1-CD107a), sialomucin core protein 24 (CD164), Raph blood group (CD151), and integrins (ITGB1 and ITGA2). This representation of the protein molecules on the EV surface may provide valuable information on NSCLC subtypes and offer new diagnostic opportunities as next-generation biomarkers in personalized oncology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza