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Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review.
Etrusco, Andrea; Laganà, Antonio Simone; Chiantera, Vito; Mikus, Mislav; Arsalan, Hafiz Muhammad; d'Amati, Antonio; Vitagliano, Amerigo; Cicinelli, Ettore; Favilli, Alessandro; D'Amato, Antonio.
Afiliación
  • Etrusco A; Unit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, 90127 Palermo, Italy.
  • Laganà AS; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
  • Chiantera V; Unit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, 90127 Palermo, Italy.
  • Mikus M; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
  • Arsalan HM; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
  • d'Amati A; Unit of Gynecologic Oncology, National Cancer Institute-IRCCS-Fondazione "G. Pascale", 80131 Naples, Italy.
  • Vitagliano A; Department of Obstetrics and Gynecology, Clinical Hospital Center Zagreb, 10 000 Zagreb, Croatia.
  • Cicinelli E; Faculty of General Medicine, Altamimi Bachelor Clinical University, Bishkek 720000, Kyrgyzstan.
  • Favilli A; Gynaecological Pathology Unit, Anatomical Pathology Division, Department of Woman and Child's Health and Public Health Sciences, "Agostino Gemelli" Foundation IRCCS University Hospital, 00168 Rome, Italy.
  • D'Amato A; Unit of Human Anatomy and Histology, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.
Biomolecules ; 14(3)2024 Mar 05.
Article en En | MEDLINE | ID: mdl-38540726
ABSTRACT

BACKGROUND:

Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST.

METHODS:

A comprehensive search of the literature was carried out on the following databases MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies that reported the oncologic and reproductive outcomes of patients with stage IA and G2EC tumors who underwent FST were considered eligible for inclusion in this systematic review (CRD42023484892). Studies describing only the FST for endometrial hyperplasia or G1 EC were excluded.

RESULTS:

Twenty-two papers that met the abovementioned inclusion criteria were included in the present systematic review. Preliminary analysis suggested encouraging oncologic and reproductive outcomes after FST.

CONCLUSIONS:

The FST approach may represent a feasible and safe option for women of childbearing age diagnosed with G2EC. Despite these promising findings, cautious interpretation is warranted due to inherent limitations, including heterogeneity in study designs and potential biases. Further research with standardized methodologies and larger sample sizes is imperative for obtaining more robust conclusions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Preservación de la Fertilidad Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Preservación de la Fertilidad Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza