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Antiadhesive Hyaluronic Acid-Based Wound Dressings Promote Wound Healing by Preventing Re-Injury: An In Vivo Investigation.
Kim, Da Som; Seong, Keum-Yong; Lee, Hyeseon; Kim, Min Jae; An, Sung-Min; Jeong, Jea Sic; Kim, So Young; Kang, Hyeon-Gu; Jang, Sangsoo; Hwang, Dae-Youn; Seo, Sung-Baek; Jo, Seong-Min; Yang, Seung Yun; An, Beum-Soo.
Afiliación
  • Kim DS; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Seong KY; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Lee H; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Kim MJ; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • An SM; Division of Endocrinology, Department of Internal Medicine, University of California Davis School of Medicine, Davis, CA 95817, USA.
  • Jeong JS; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Kim SY; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Kang HG; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Jang S; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Hwang DY; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Seo SB; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Jo SM; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • Yang SY; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
  • An BS; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea.
Biomedicines ; 12(3)2024 Feb 23.
Article en En | MEDLINE | ID: mdl-38540123
ABSTRACT
Wound dressings are widely used to protect wounds and promote healing. The water absorption and antifriction properties of dressings are important for regulating the moisture balance and reducing secondary damages during dressing changes. Herein, we developed a hyaluronic acid (HA)-based foam dressing prepared via the lyophilization of photocrosslinked HA hydrogels with high water absorption and antiadhesion properties. To fabricate the HA-based foam dressing (HA foam), the hydroxyl groups of the HA were modified with methacrylate groups, enabling rapid photocuring. The resulting photocured HA solution was freeze-dried to form a porous structure, enhancing its exudate absorption capacity. Compared with conventional biopolymer-based foam dressings, this HA foam exhibited superior water absorption and antifriction properties. To assess the wound-healing potential of HA foam, animal experiments involving SD rats were conducted. Full-thickness defects measuring 2 × 2 cm2 were created on the skin of 36 rats, divided into four groups with 9 individuals each. The groups were treated with gauze, HA foam, CollaDerm®, and CollaHeal® Plus, respectively. The rats were closely monitored for a period of 24 days. In vivo testing demonstrated that the HA foam facilitated wound healing without causing inflammatory reactions and minimized secondary damages during dressing changes. This research presents a promising biocompatible foam wound dressing based on modified HA, which offers enhanced wound-healing capabilities and improved patient comfort and addresses the challenges associated with conventional dressings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article Pais de publicación: Suiza