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Antibacterial Properties of Bacterial Endophytes Isolated from the Medicinal Plant Origanum heracleoticum L.
Semenzato, Giulia; Bernacchi, Alberto; Amata, Sara; Bechini, Angela; Berti, Fabiola; Calonico, Carmela; Catania, Valentina; Esposito, Antonia; Puglia, Anna Maria; Piccionello, Antonio Palumbo; Emiliani, Giovanni; Biffi, Sauro; Fani, Renato.
Afiliación
  • Semenzato G; Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy.
  • Bernacchi A; Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy.
  • Amata S; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies-STEBICEF, University of Palermo, 90128 Palermo, Italy.
  • Bechini A; Department of Health Sciences, University of Florence, 50134 Florence, Italy.
  • Berti F; Department of Health Sciences, University of Florence, 50134 Florence, Italy.
  • Calonico C; Department of Health Sciences, University of Florence, 50134 Florence, Italy.
  • Catania V; Department of Earth and Sea Science (DiSTeM), University of Palermo, 90128 Palermo, Italy.
  • Esposito A; Council for Agricultural and Economics Research (CREA) - Agriculture and Environment, 50125 Florence, Italy.
  • Puglia AM; Consorzio Italbiotec, 20126 Milan, Italy.
  • Piccionello AP; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies-STEBICEF, University of Palermo, 90128 Palermo, Italy.
  • Emiliani G; Institute for Sustainable Plant Protection (IPSP)-National Research Council (CNR), 50019 Sesto Fiorentino, Italy.
  • Biffi S; Giardino delle Erbe Augusto Rinaldi Ceroni, 48032 Ravenna, Italy.
  • Fani R; Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy.
Front Biosci (Landmark Ed) ; 29(3): 111, 2024 Mar 19.
Article en En | MEDLINE | ID: mdl-38538270
ABSTRACT

BACKGROUND:

Bacterial endophytic communities associated with medicinal plants synthesize a plethora of bioactive compounds with biological activities. Their easy isolation and growth procedures make bacterial endophytes an untapped source of novel drugs, which might help to face the problem of antimicrobial resistance. This study investigates the antagonistic potential of endophytic bacteria isolated from different compartments of the medicinal plant O. heracleoticum against human opportunistic pathogens.

METHODS:

A panel of endophytes was employed in cross-streaking tests against multidrug-resistant human pathogens, followed by high-resolution chemical profiling using headspace-gas chromatography/mass spectrometry.

RESULTS:

Endophytic bacteria exhibited the ability to antagonize the growth of opportunistic pathogens belonging to the Burkholderia cepacia complex (Bcc). The different inhibition patterns observed were related to their taxonomic attribution at the genus level; most active strains belong to the Gram-positive genera Bacillus, Arthrobacter, and Pseudarthrobacter. Bcc strains of clinical origin were more sensitive than environmental strains. Cross-streaking tests against other 36 human multidrug-resistant pathogens revealed the highest antimicrobial activity towards the Coagulase-negative staphylococci and Klebsiella pneumoniae strains. Interestingly, strains of human origin were the most inhibited, in both groups. Concerning the production of volatile organic compounds (VOCs), the strain Arthrobacter sp. OHL24 was the best producer of such compounds, while two Priestia strains were good ketones producers and so could be considered for further biotechnological applications.

CONCLUSIONS:

Overall, this study highlights the diverse antagonistic activities of O. heracleoticum-associated endophytes against both Bcc and multidrug-resistant (MDR) human pathogens. These findings hold important implications for investigating bacterial endophytes of medicinal plants as new sources of antimicrobial compounds.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Origanum Límite: Humans Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Origanum Límite: Humans Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Singapur