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Histopathological and Immunohistochemical Mechanisms of Bone Marrow-Derived Mesenchymal Stem Cells in Reversion of Gastric Precancerous Lesions.
Chen, Qian-Qian; Wang, Cong; Wang, Wei-Hua; Gong, Yuan; Chen, Hai-Xu.
Afiliación
  • Chen QQ; Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
  • Wang C; Department of Gastroenterology and Hepatology, The Second Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
  • Wang WH; Medical School of Chinese PLA, 100853 Beijing, China.
  • Gong Y; Department of Gastroenterology and Hepatology, The Second Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
  • Chen HX; Department of Gastroenterology and Hepatology, The Second Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
Front Biosci (Landmark Ed) ; 29(3): 127, 2024 Mar 22.
Article en En | MEDLINE | ID: mdl-38538255
ABSTRACT

BACKGROUND:

Gastric cancer (GC) stands as one of the most prevalent cancer types worldwide, holding the position of the second leading cause of cancer-related deaths. Gastric lesions represent pathological alterations to the gastric mucosa, with an elevated propensity to advance to gastric cancer. Limited research has explored the potential of stem cells in the treatment of gastric lesions.

METHODS:

This study aimed to explore the potential of intravenous transplantation of labeled bone marrow-derived mesenchymal stem cells (BMMSCs) to inhibit the progression of precancerous gastric lesions.

RESULTS:

In the gastric lesion disease model group, the rat tissue exhibited noteworthy mucosal atrophy, intestinal metaplasia, dysplasia, and inflammatory cell infiltration. Following the infusion of BMMSCs, a notable decrease in gastric lesions was found, with atrophic gastritis being the sole remaining lesion, which was confirmed by morphological and histological examinations. BMMSCs that were colonized at gastric lesions could differentiate into epithelial and stromal cells, as determined by the expression of pan-keratin or vimentin. The expression of vascular endothelial growth factor was significantly elevated following BMMSC transplantation. BMMSCs could also upregulate the production of humoral immune response cytokines, including interleukin (IL)-4 and IL-10, and downregulate the production of IL-17 and interferon-gamma, which could be highly associated with the cellular immune response and inflammation severity of the lesions.

CONCLUSIONS:

BMMSC transplantation significantly reduced inflammation and reversed gastric lesion progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Gástricas / Células Madre Mesenquimatosas Límite: Animals Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Gástricas / Células Madre Mesenquimatosas Límite: Animals Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur