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Results of Definitive (Chemo)radiotherapy Using Computed Tomography-based Brachytherapy for Cervical Cancer.
Aoshika, Tomomi; Noda, Shin-Ei; Abe, Takanori; Kumazaki, Y U; Hirai, Ryuta; Igari, Mitsunobu; Saito, Satoshi; Ryuno, Yasuhiro; Iino, Misaki; Takeda, Yuga; Ohta, Tomohiro; Watanabe, Jun; Tsukahara, Keita; Kato, Shingo.
Afiliación
  • Aoshika T; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Noda SE; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Abe T; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Kumazaki YU; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Hirai R; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Igari M; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Saito S; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Ryuno Y; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Iino M; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Takeda Y; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Ohta T; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Watanabe J; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Tsukahara K; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
  • Kato S; Department of Radiation Oncology, International Medical Center, Saitama Medical University, Saitama, Japan s_kato@saitama-med.ac.jp.
Anticancer Res ; 44(4): 1583-1589, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38537975
ABSTRACT
BACKGROUND/

AIM:

Concurrent cisplatin-based chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer. Especially, CCRT with magnetic resonance imaging (MRI) or computed tomography-based image-guided brachytherapy (CT-based 3D-IGBT) for cervical cancer has resulted in good LC rates. However, progression-free survival (PFS) and overall survival (OS) rates for locally advanced cervical cancer are still low and could be improved. The aim of the study was to evaluate treatment efficacy and late toxicity of external beam radiotherapy (EBRT) and CT-based IGBT with or without concurrent chemotherapy in patients with squamous cell carcinoma of the uterine cervix and investigate patterns of failure. PATIENTS AND

METHODS:

We retrospectively analyzed clinical data of cervical squamous cell carcinoma patients treated with definitive radiotherapy with or without concurrent chemotherapy at Saitama Medical University International Medical Center. Local control (LC), PFS, patterns of failure, and late toxicity were the evaluated outcomes.

RESULTS:

Overall, 290 patients were enrolled in the study. Median follow-up was 51.5 months. During follow-up, 74 patients developed recurrence 10 patients with intra-pelvic failure only, 45 with extra-pelvic failure only, and 19 with both. The 3-year LC was 100% for T1b-T2a, 96.8% for T2b, 89.5% for T3b, and 88.5% for T4 disease. The 3-year PFS was 100% for stage IB-IIA, 89.0% for stage IIB, 70.7% for stage IIIB, 72.6% for stage IIIC1r, and 40.1% for stage IVA. The incidence of grade 3-4 gastrointestinal and genitourinary toxicities was 3.0% and 1.7%, respectively.

CONCLUSION:

Combination of EBRT and CT-based IGBT with or without concurrent chemotherapy produced favorable LC with acceptable rates of late toxicities. However, extra-pelvic failures frequently occurred and PFS was less satisfactory in patients with stage III-IVA disease, which indicated the need for additional treatment in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Carcinoma de Células Escamosas / Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Carcinoma de Células Escamosas / Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia