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Metabolic Tumor Volume as Significant Predictor for Chemotherapy Containing PD-L1 Blocker in Extensive Stage Small Cell Lung Cancer.
Hashimoto, Kosuke; Kaira, Kyoichi; Imai, Hisao; Miura, Y U; Shiono, Ayako; Mouri, Atsuto; Yamaguchi, O U; Kobayashi, Kunihiko; Kagamu, Hiroshi; Kuji, Ichiei.
Afiliación
  • Hashimoto K; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Kaira K; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan kkaira1970@yahoo.co.jp.
  • Imai H; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Miura YU; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Shiono A; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Mouri A; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Yamaguchi OU; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Kobayashi K; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Kagamu H; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Kuji I; Department of Nuclear Medicine, International Medical Center, Saitama Medical University, Hidaka, Japan.
Anticancer Res ; 44(4): 1541-1551, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38537960
ABSTRACT
BACKGROUND/

AIM:

Chemo-immunotherapy, including the programmed death ligand 1 (PD-L1) antibody, is an effective treatment for patients with extensive-stage small-cell lung cancer (ES-SCLC). However, no biomarker has been established for the prediction of chemo-immunotherapy. Therefore, we investigated the potential of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) as a predictive marker. PATIENTS AND

METHODS:

Forty-six patients with ES-SCLC who received 18F-FDG-PET immediately before combined platinum-based chemotherapy with PD-L1 blockade as a first-line treatment were eligible, and the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on 18F-FDG uptake were evaluated.

RESULTS:

PD-L1 and tumor infiltrative lymphocytes (TILs) were immunohistochemically analyzed in 36 of the 46 patients. A high MTV was significantly associated with poor performance status and low albumin levels, and there was a significant association between low albumin and high TLG. Univariate analysis identified sex, Brinkman index, and MTV as significant predictors of progression-free survival (PFS), and sex, SUVmax, MTV, and TLG as significant factors of overall survival (OS). Multivariate analysis revealed that sex, Brinkman index, and MTV were independent prognostic factors for PFS, and sex, SUVmax, MTV, and TLG were significant predictors of OS. SUVmax was significantly higher in patients with positive PD-L1 expression than in those with negative expression but was not significantly different between positive and negative TILs. Moreover, the levels of MTV and TLG were not closely associated with the levels of PD-L1 and TILs.

CONCLUSION:

MTV or TLG metabolic tumor activity is suitable for the prediction of chemo-immunotherapy outcomes in patients with ES-SCLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia