Your browser doesn't support javascript.
loading
Roles of Matrix Metalloproteinases 2 and 9 in Uterine Leiomyosarcoma.
Wang, Xiye; Li, Chunrong; Lou, Luqing; Zhu, Haibin.
Afiliación
  • Wang X; Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
  • Li C; Department of Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang) University School of Medicine, the Shengzhou Hospital of Shaoxing, Shaoxing, P.R. China.
  • Lou L; Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
  • Zhu H; Department of Gynecology, The First People's Hospital of Lin'an District, Hangzhou City, P.R. China.
Anticancer Res ; 44(4): 1465-1473, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38537953
ABSTRACT
BACKGROUND/

AIM:

Uterine leiomyosarcoma (uLMS) is a rare, highly malignant, and invasive cancer, with early metastasis. Mismatch repair (MMR) proteins and matrix metalloproteinases (MMPs) are associated with the occurrence, proliferation, and invasion of most malignant cancers; however, their abnormal expression in uLMS remains poorly clarified. PATIENTS AND

METHODS:

Immunohistochemistry was performed to assess MMR protein and MMP2/9 expression as well as Ki67 marker proliferation in benign and malignant uterine smooth muscle tumors. Data from 28 cases of uterine leiomyoma and 31 cases of uLMS were analyzed.

RESULTS:

Tumor tissues from patients with uLMS had higher expression levels of MMP2 (p<0.001), MMP9 (p<0.05), and Ki67 (p<0.001) than those from patients with uterine leiomyoma; MMR protein expression showed the opposite trend (p<0.05). uLMS proliferation and metastasis correlated positively with MMP2 (p=0.012 and 0.015, respectively) but negatively with MMP9 (p=0.021 and 0.04, respectively). MMR protein expression did not correlate with uLMS proliferation or metastasis (p>0.05).

CONCLUSION:

Expression levels of MMP2 and MMP9 were upregulated in malignant uLMS tumors when compared with those in benign uterine leiomyoma tumors. Increased MMP2 expression might promote uLMS invasion and migration. MMP9 overexpression might be related to uLMS occurrence; however, it protects against uLMS invasion and metastasis. MMP2 and MMP9 may be potential predictors of uLMS cell proliferation, metastasis, and prognosis. These findings could be helpful in developing new strategies for diagnosing and treating uLMS.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pélvicas / Neoplasias Uterinas / Leiomioma / Leiomiosarcoma Límite: Female / Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pélvicas / Neoplasias Uterinas / Leiomioma / Leiomiosarcoma Límite: Female / Humans Idioma: En Revista: Anticancer Res Año: 2024 Tipo del documento: Article Pais de publicación: Grecia