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Assessment of hemostatic ability of biomaterial based on chitosan andEclipta prostrataL. extract.
Linh, Nguyen Ngoc; Manh, Vu Quoc; Chau Giang, La; Chinh, Nguyen Thuy; Dung, Hoang Tran; Thuy Duong, Tran Thi; Hoang, Thai; Trung, Vu Quoc.
Afiliación
  • Linh NN; Faculty of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc, Hanoi 10000, Vietnam.
  • Manh VQ; Faculty of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc, Hanoi 10000, Vietnam.
  • Chau Giang; Hanoi-Amsterdam High School for the Gifted, 1 Hoang Minh Giam, Cau Giay, Hanoi 10000, Vietnam.
  • Chinh NT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam.
  • Dung HT; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam.
  • Thuy Duong TT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam.
  • Hoang T; Tay Ho High School, 143 Phu Gia, Phu Thuong, Tay Ho, Hanoi 10000, Vietnam.
  • Trung VQ; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam.
Biomed Mater ; 19(3)2024 Apr 04.
Article en En | MEDLINE | ID: mdl-38537280
ABSTRACT
The biomaterials based on chitosan andEclipta prostrataL. extract have been prepared by microemulsion method and solution method (with and without sodium tripolyphosphate (STPP) as a cross-linking agent). The main component inEclipta prostrataL. extract is flavonoid groups. The structure of the chitosan/extract biomaterials was studied by infrared spectroscopy. The chitosan/extract biomaterial using STPP cross-linker appeared an absorption band at 1152 cm-1attributed to the vibrations of C-O-P bonds, which proved that chitosan has crosslinked with STPP. The morphology of the biomaterials was investigated by the dynamic light scattering technique and field emission scanning electron microscopy. The obtained results showed that the particle size of the chitosan/extract biomaterials prepared by microemulsion method and solution method with STPP ranged from 68.06 nm to 1484 nm, with an average particle size of 304.9-1019 nm. The microemulsion method produced biomaterials with much smaller average particle size than the solution method using cross-linkers. The hemostatic ability of the biomaterials was better than that of the control sample based on the time of blood clotting formation and glomerular aggregation ability. The sample with the ratio ofE. prostrataL. extract chitosan of 130 had the lowest hemostasis time (6 min 46 s) and its glomerular aggregation rate after 5 min was 13.05%. This indicated that the biomaterials based on chitosan andE. prostrataL. extract are promising for application in biomedicine as hemostatic materials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemostáticos / Quitosano Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemostáticos / Quitosano Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido